Odd chain fatty acids; New insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolérance

Benjamin J. Jenkins (1) , Kévin Seyssel (2) , Sally Chiu (3) , Pin-Ho Pan (4) , Shih-Yi Lin (5) , Elizabeth Stanley (1) , Zsuzsanna Ament (1) , James A. West (1) , Keith Summerhill (1) , Julian L. Griffin (1) , Walter Vetter (6) , Kaija J. Autio (7) , Kalervo Hiltunen (7) , Stéphane Hazebrouck (8) , Renata Stepankova (9) , Chun-Jung Chen (10) , Maud Alligier (2) , Martine Laville (2) , Mary Moore (11) , Guillaume Kraft (11) , Alan Cherrington (11) , Sarah King (3) , Ronald M. Krauss (3) , Evelyn de Schryver (12) , Paul P. van Veldhoven (12) , Martin Ronis (12) , Albert Koulman (1, 13)

1 Medical Research Council Human Nutrition Research
2 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
3 Oakland Research Institute
4 Department Pediatric
5 Center Geriatric and Gerontology, Division Endocrinology and Metabolic
6 Institute Food Chemistry
7 Biocenter Oulu, Faculty Biochemistry and Molecular Medicine
8 LERI - Laboratoire d'Etudes et de Recherches en Immunoanalyses
9 Institute Microbiology, Laboratory of Gnotobiology
10 Department of Medical Research
11 School Medicine, Department Molecular Physiology and Biophysics
12 Laboratory Lipid Biochemistry and Protein Interaction LIPIT
13 NIHR BRC Core Metabolic aand Lipid Laboratory

Recent findings have shown an inverse association between circulating C15: 0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatty acids from the gut-microbiota, the diet, and novel endogenous biosynthesis. Investigations included an intestinal germ-free study and a C15:0/C17:0 diet dose response study. Endogenous production was assessed through: a stearic acid infusion, phytol supplementation, and a Hacl1(-/-) mouse model. Two human dietary intervention studies were used to translate the results. Finally, a study comparing baseline C15:0/C17:0 with the prognosis of glucose intolerance. We found that circulating C15:0/C17:0 levels were not influenced by the gut-microbiota. The dose response study showed C15:0 had a linear response, however C17:0 was not directly correlated. The phytol supplementation only decreased C17:0. Stearic acid infusion only increased C17:0. Hacl1(-/-) only decreased C17:0. The glucose intolerance study showed only C17:0.

Mots clés: fatty acid; biosynthesis

Mots clés: acide gras; glucose; microbiote digestif; apport alimentaire; biosynthèse; intolérance

Domaines: Sciences du Vivant [q-bio]

Benjamin J. Jenkins, Kévin Seyssel, Sally Chiu, Pin-Ho Pan, Shih-Yi Lin, et al.. Odd chain fatty acids; New insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolérance. Scientific Reports, 2017, 7, ⟨10.1038/srep44845⟩. ⟨hal-01606576⟩