Skip to Main content Skip to Navigation
Poster communications

Une nouvelle facette du génome de poule : les genes “longs non-codants"

Abstract : Recent works in humans and model organisms have shown a massive new type of genes: genes transcribed into long RNAs (≥ 200 nt) but not coding for proteins - these genes are called long noncoding RNA genes (lncRNA). These lncRNAs are a major component of the transcriptome and only a small fraction of them is described in public databases. Our study conducted on chicken shows that transcriptomic sequencing (RNA-Seq) on multiple biological replicates of two tissues (liver and adipose tissue) allows us to predict a lncRNA catalog for these two tissues more exhaustive than lncRNAs catalog available in public databases. We also confirm that chicken lncRNA features are similar to those of human and murine lncRNAs described in the literature (shorter transcripts, less exons, sequences less conserved across species, more tissue-specific expression and lower expression than protein coding RNAs (mRNA)). In conclusion, we provide a comprehensive lncRNA repertoire in the chicken liver and adipose tissue and we highlighte a new lncRNA-mRNA pair in divergent position in the chicken genome (as in the human genome), highly co-expressed suggesting a common regulation mechanism through a bidirectional promoter and probably involved in cholesterol metabolism.
Document type :
Poster communications
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-01605848
Contributor : Archive Ouverte Prodinra <>
Submitted on : Monday, October 2, 2017 - 10:06:12 PM
Last modification on : Friday, February 5, 2021 - 4:17:17 PM

Licence


Distributed under a Creative Commons Attribution - ShareAlike 4.0 International License

Identifiers

  • HAL Id : hal-01605848, version 1
  • PRODINRA : 392007

Citation

Kévin Muret, Christophe Klopp, Valentin Wucher, Diane Esquerre, Fabrice Legeai, et al.. Une nouvelle facette du génome de poule : les genes “longs non-codants". 12. Journées de la Recherche Avicole et des Palmipèdes à Foie Gras, Apr 2017, Tours, France. ITAVI - Institut Technique de l'Aviculture, Journées de la Recherche Avicole et des Palmipèdes à Foie Gras, 2017, Journées de la Recherche Avicole et des Palmipèdes à Foie Gras. ⟨hal-01605848⟩

Share

Metrics

Record views

436