Multi-objective particle swarm optimization (MOPSO) of lipid accumulation in Fed-batch cultures

C E Robles Rodriguez (1) , Carine Bideaux (1) , Stéphane Guillouet (1) , Nathalie Gorret (1) , G. Roux (1, 2, 3) , Carole Molina-Jouve (1) , Cesar Arturo Aceves-Lara (1)

1 LISBP - Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés
2 CNRS - Centre National de la Recherche Scientifique
3 UT3 - Université Toulouse III - Paul Sabatier

Dynamic optimization of fermentation processes could demand the use of multiple criteria to attain certain objectives, which in most cases are conflicting to each other. The use of Pareto optimal sets supplies the necessary information to take decisions about the trade-offs between objectives. In this work, a multi-objective optimization algorithm based on particle swarm optimization (MOPSO) is used to optimize lipid contents in fermentations with Yarrowia lipolytica. A reduced model was developed to shorten the computation time of MOPSO. A pattern search algorithm was sequentially coupled to MOPSO to execute a dynamic optimization handling physical constraints. Three cases are analyzed to emphasize the response of our control strategy. Simulation results showed that MOPSO - pattern search algorithm achieved high lipid fraction and productivity.

Mots clés: Multi-objective optimization; Particle swarm optimization; Pattern search; Fed-batch fermentation; Lipid accumulation

Domaines: Sciences du Vivant [q-bio]

C E Robles Rodriguez, Carine Bideaux, Stéphane Guillouet, Nathalie Gorret, G. Roux, et al.. Multi-objective particle swarm optimization (MOPSO) of lipid accumulation in Fed-batch cultures. 24th Mediterranean Conference on Control and Automation (MED), Jun 2016, Athens, Greece. pp.6. ⟨hal-01602874⟩