Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: comprehensive study of mechanisms

Jordan Seira (1) , Caroline Sablayrolles (1) , Mireille Vignoles (1) , Claire Albasi (2) , Claire Joannis-Cassan (2)

1 CAI - Chimie Agro-Industrielle
2 LGC - Laboratoire de Génie Chimique

The mechanisms of elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor were investigated. The membrane bioreactor was run for 153 days with a sludge retention time (SRT) of 20 days. A removal efficiency of 60% was observed despite some variations in the influent. This removal was higher than reported in most of the studies in the literature. Biodegradation was the predominant removal mechanism and sorption onto sludge could be neglected.

Mots clés: pollution abatement; medications; Membrane bioreactor (MBR); Wastewater treatment; Pharmaceuticals; Cyclophosphamid; Biodegradation rate; Sorption

Mots clés: bioréacteur à membrane; gestion des eaux usées; dépollution; cyclophosphamide; biodégradation; produit pharmaceutique

Domaines: Génie chimique; Génie des procédés

Jordan Seira, Caroline Sablayrolles, Mireille Vignoles, Claire Albasi, Claire Joannis-Cassan. Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: comprehensive study of mechanisms. Biochemical Engineering Journal, 2016, 114, pp.155-163. ⟨10.1016/j.bej.2016.07.001⟩. ⟨hal-01595535⟩