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Biobased 3-hydroxypropionic acid through a new integrated process of glycerol bioconversion and membrane-assisted reactive extraction.

Abstract : Tremendous growth of biodiesel manufacturing industries --> glycerol as a main byproduct. Need for developing biotechnological processes to convert glycerol into high-added value chemicals. 3-Hydroxypropionic acid (3-HP): significant platform chemical from which various specialty chemicals can be synthesized. Currently produced by chemical methods, but biotechnological production not well established Until now, among lactic acid bacteria, only bacteria of the Lactobacillus genus and specially L. reuteri have been shown to produce 3-HP from glycerol, although at low productivity. 3-HP and its metabolic intermediate 3-hydroxypropionaldehyde (3-HPA) are suspected to exhibit inhibitory or toxic effects on the producing microorganisms --> ISPR (In Situ Product Recovery) = potential strategy to relieve the stress, increase the performance of microbial cells and recover the molecule of interest => Study of the impact of the integrated process on bioconversion productivity and cell physiological state.
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https://hal.archives-ouvertes.fr/hal-01586230
Contributor : Claire Saulou-Bérion <>
Submitted on : Tuesday, September 12, 2017 - 4:05:23 PM
Last modification on : Tuesday, March 17, 2020 - 2:51:23 AM
Long-term archiving on: : Wednesday, December 13, 2017 - 3:41:46 PM

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  • HAL Id : hal-01586230, version 1

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Grégoire Burgé, Florian Chemarin, Claire Saulou-Berion, Henry-Eric Spinnler, Violaine Athes-Dutour, et al.. Biobased 3-hydroxypropionic acid through a new integrated process of glycerol bioconversion and membrane-assisted reactive extraction.. Nordic-French Research Dialogue "Biomass Conversion: Green Chemistry & Innovative Processes" , Mar 2016, Paris, France. 2016. ⟨hal-01586230⟩

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