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Integrated approach combining microbiological processes and in situ product recovery for the production of 3-hydroxypropionic acid by Lactobacillus reuteri

Abstract : In the actual environmental and economic context, there is an increased interest in the microbial production at a large industrial scale of the bifunctional weak carboxylic acid 3-hydroxypropionic acid (3-HP). Among its various applications, this compound could be used as building block mainly for the synthesis of bio-based polymers. Moreover, in recent years, the tremendous growth of biodiesel manufacturing industries resulted in a large production of inexpensive and abundant available glycerol as by-product that could be used as substrate. In the present work, the bioconversion of glycerol into 3-HP by Lactobacillus reuteri was studied. Product and its metabolic intermediate 3-hydroxypropionaldehyde (3-HPA) are suspected to exhibit inhibitory or toxic effects on the producing microorganisms, thus leading to low productivity and dilute product stream. This entails high costs for isolation and purification of the product. A potential strategy to relieve the inhibitory stress, to increase the performance of the microbial cells and to recover the molecule of interest is to implement an “In Situ Product Recovery” (ISPR), by which upstream bioconversion is combined to downstream extraction and recovery.
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https://hal.archives-ouvertes.fr/hal-01585790
Contributor : Claire Saulou-Bérion <>
Submitted on : Tuesday, September 12, 2017 - 9:20:38 AM
Last modification on : Tuesday, March 17, 2020 - 2:51:23 AM

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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

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  • HAL Id : hal-01585790, version 1

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Grégoire Burgé, Marwen Moussa, Claire Saulou-Berion, Violaine Athes-Dutour, Henry-Eric Spinnler. Integrated approach combining microbiological processes and in situ product recovery for the production of 3-hydroxypropionic acid by Lactobacillus reuteri. Journée de l'école doctorale ABIES 2014, 2014, Paris, France. 2014. ⟨hal-01585790⟩

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