Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process

Abstract : Nonsteroidal 2-arylproprionic acids are widely used, over-the-counter, anti-inflammatory drugs. Photosensitivity is a commonly overlooked adverse effect of these drugs. Based on the combined use of cell viability assays and molecular modeling, we prove and rationalize the photochemical pathways triggering photosensitization for two drugs, ibuprofen and ketoprofen. As its parent compound benzophenone, ketoprofen produces singlet oxygen, upon triplet manifold population. However, ibuprofen and ketoprofen photodissociate and hence may generate two highly reactive radicals. The formation of metastable aggregates between the two drugs and B-DNA is also directly probed by molecular dynamics. Our approach characterizes the coupled influence of the drug's intrinsic photochemistry and the interaction pattern with DNA. The photosensitization activity of nonsteroidal 2-arylproprionic acids, being added to gels and creams for topical use, should be crucially analyzed and rationalized to enact the proper preventive measures.
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Scientific Reports, Nature Publishing Group, 2017, 7, pp. Article Number: 8885 〈10.1038/s41598-017-09406-8〉
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https://hal.archives-ouvertes.fr/hal-01583391
Contributeur : Agnès Bussy <>
Soumis le : jeudi 7 septembre 2017 - 11:56:07
Dernière modification le : jeudi 8 février 2018 - 11:10:27

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Emmanuelle Bignon, Marco Marazzi, Vanessa Besancenot, Hugo Gattuso, Guillaume Drouot, et al.. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process . Scientific Reports, Nature Publishing Group, 2017, 7, pp. Article Number: 8885 〈10.1038/s41598-017-09406-8〉. 〈hal-01583391〉

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