Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies.

S Schmitt (1) , N Colloc'H (2) , C Perrio (1)

1 LDM-TEP - Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons
2 CERVOxy - Hypoxie, physiopathologies cérébrovasculaire et tumorale

Mots clés: 4R)-3; (3R; 4-dimethyl-4-(3-hydroxyphenyl)piperidine; Docking; JDTic; Kappa opioid receptor; Selectivity

Domaines: Sciences du Vivant [q-bio]

S Schmitt, N Colloc'H, C Perrio. Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies.. European Journal of Medicinal Chemistry, 2015, 90, pp.742-50. ⟨10.1016/j.ejmech.2014.12.016⟩. ⟨hal-01576209⟩