Rapid improvement in visual function after high-dose oral corticosteroids in patients with inflammatory optic neuropathy

Abstract : PURPOSE: To study the progression of visual acuity and visual function parameters in patients with optic neuritis (ON) treated with high-dose oral corticosteroid therapy. METHODS: This retrospective descriptive monocentric study included nine patients with ON treated with orally administered methylprednisolone at 1000 mg per day for three to five days. The follow-up visits were performed on day 4 (D4), day 15 (D15), day 30 (D30) and day 90 (D90) after treatment was begun. The initial examination (D0) and the follow-up visits included a visual acuity (VA) assessment according to the Early Treatment Diabetic Retinopathy Study scale, a contrast sensitivity test and a 30.2 automated visual field (Visual Field Index [VFI]). The overall subjective tolerance of the treatment was assessed by patients on a scale from 0 to 10. RESULTS: We observed an improvement of all parameters from D4. From D0 to D4, the average VA increased from 40.1 letters to 57.9 letters, the average VFI from 40.9% to 70.3% and the overall average contrast sensitivity from 7.7 dB to 11.3 dB. From D15 to D90, the average VA increased from 77 letters to 80.3 letters, the average VFI from 91.2% to 97.9% and the overall average contrast sensitivity from 15.4 dB to 16.7 dB. Four patients rated tolerance at 10 (excellent), three between 8 and 9, and two at 6. CONCLUSION: We demonstrated rapid improvement of visual function parameters in patients with ON after high-dose oral corticosteroids.
Type de document :
Article dans une revue
Journal Français D'Ophtalmologie, Elsevier Masson, 2016, 39 (8), pp.691-699. 〈10.1016/j.jfo.2016.03.008〉
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01575799
Contributeur : Carole Brunaud <>
Soumis le : lundi 21 août 2017 - 16:46:29
Dernière modification le : vendredi 15 février 2019 - 01:29:28

Identifiants

Citation

A Poujade, E Le Page, D Baudet, Gilles Edan, B Mortemousque, et al.. Rapid improvement in visual function after high-dose oral corticosteroids in patients with inflammatory optic neuropathy. Journal Français D'Ophtalmologie, Elsevier Masson, 2016, 39 (8), pp.691-699. 〈10.1016/j.jfo.2016.03.008〉. 〈hal-01575799〉

Partager

Métriques

Consultations de la notice

130