Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images

Alwin Zweerink (1) , Cornelis P. Allaart (1) , Joost P. Kuijer (2) , Lina Wu (1) , Aernout M. Beek (1) , Peter van de Ven (3) , Mathias Meine (4) , Pierre Croisille (5) , Patrick Clarysse (6) , Albert C. van Rossum (1) , Robin Nijveldt (1)

1 ICaR-VU
2 Department of Physics and Medical Technology
3 Department of Clinical Epidemiology and Biostatistics
4 Department of Cardiology
5 RMN et optique : De la mesure au biomarqueur
6 MOTIVATE - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales

ObjectivesAlthough myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates.MethodsTwenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated.ResultsSegmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61).ConclusionsThe novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available.Key Points• Myocardial strain analysis could potentially improve patient selection for CRT.• Currently a well validated clinical approach to derive segmental strains is lacking.• The novel SLICE technique derives segmental strains from standard CMR cine images.• SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG.• Future studies will focus on the prognostic value of SLICE in CRT candidates.

Mots clés: Segment length in cine (SLICE) technique; Cardiovascular magnetic resonance (CMR); Myocardial strain analysis; Myocardial tagging (CMR-TAG); Cardiac Resynchronization Therapy (CRT)

Domaines: Traitement du signal et de l'image [eess.SP]; Imagerie

Alwin Zweerink, Cornelis P. Allaart, Joost P. Kuijer, Lina Wu, Aernout M. Beek, et al.. Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images. European Radiology, 2017, 27 (12), pp.5158-5158. ⟨10.1007/s00330-017-4890-0⟩. ⟨hal-01572436⟩