A combined neutron scattering and simulation study on bioprotectant systems

F. Migliardo , A.J. Ramirez-Cuesta , M.F.T. Telling , Frederic Affouard , Patrice Bordat (1) , Michel Descamps , Adrien Lerbret , S. Magazù

1 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

The present work shows quasi elastic neutron scattering, neutron spin echo and inelastic neutron scattering results on a class of bioprotectant systems, such as homologous disaccharides (i.e., trehalose and sucrose)/water solutions, as a function of temperature. The whole set of findings indicates a noticeable "kosmotrope" character of the disaccharides, and in particular of trehalose, which is able to strongly modify both the structural and dynamical properties of water. This superior capability of trehalose can be linked to its higher bioprotective effectiveness in respect with the other disaccharides. © 2005 Elsevier B.V. All rights reserved.

Mots clés: Bioprotective effects; Disaccharides; Dynamical properties; Neutron scattering; Water mixtures

Domaines: Chimie

F. Migliardo, A.J. Ramirez-Cuesta, M.F.T. Telling, Frederic Affouard, Patrice Bordat, et al.. A combined neutron scattering and simulation study on bioprotectant systems. Chemical Physics, 2005, 317 (2-3), pp.258--266. ⟨10.1016/j.chemphys.2005.05.033⟩. ⟨hal-01567181⟩