PyHRF: A Python Library for the Analysis of fMRI Data Based on Local Estimation of the Hemodynamic Response Function

Jaime Arias (1) , Philippe Ciuciu (2, 3, 4) , Michel Dojat (5, 6) , Florence Forbes (1) , Aina Frau-Pascual (1) , Thomas Perret (1) , Jan M Warnking (5, 6)

1 MISTIS - Modelling and Inference of Complex and Structured Stochastic Systems
2 IFR49 - Neurospin - CEA
3 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data
4 Inria Saclay - Ile de France
5 GIN - [GIN] Grenoble Institut des Neurosciences
6 ANTE-INSERM U836, équipe 5 - Neuro-imagerie fonctionnelle et métabolique

Functional Magnetic Resonance Imaging (fMRI) is a neuroimaging technique that allows the non-invasive study of brain function. It is based on the hemodynamic variations induced by changes in cerebral synaptic activity following sensory or cognitive stimulation. The measured signal depends on the variation of blood oxygenation level (BOLD signal) which is related to brain activity: a decrease in deoxyhemoglobin concentration induces an increase in BOLD signal. The BOLD signal is delayed with respect to changes in synap-tic activity, which can be modeled as a convolution with the Hemodynamic Response Function (HRF) whose exact form is unknown and fluctuates with various parameters such as age, brain region or physiological conditions. In this paper we present PyHRF, a software to analyze fMRI data using a Joint Detection-Estimation (JDE) approach. It jointly detects cortical activation and estimates the HRF. In contrast to existing tools, PyHRF estimates the HRF instead of considering it as a given constant in the entire brain. Here, we present an overview of the package and showcase its performance with a real case in order to demonstrate that PyHRF is a suitable tool for clinical applications.

Mots clés: hemodynamic response function; Python; BOLD response; fMRI

Domaines: Imagerie médicale; Traitement du signal et de l'image [eess.SP]; Neurosciences; Applications [stat.AP]

Jaime Arias, Philippe Ciuciu, Michel Dojat, Florence Forbes, Aina Frau-Pascual, et al.. PyHRF: A Python Library for the Analysis of fMRI Data Based on Local Estimation of the Hemodynamic Response Function. 16th Python in Science Conference (SciPy 2017), Jul 2017, Austin, TX, United States. pp.34-40, ⟨10.25080/shinma-7f4c6e7-006⟩. ⟨hal-01566457⟩