C. Abi-khalil, C. Lopez-joven, E. Abadie, V. Savar, Z. Amzil et al., Exposure to the Paralytic Shellfish Toxin Producer Alexandrium catenella Increases the Susceptibility of the Oyster Crassostrea gigas to Pathogenic Vibrios, Toxins, vol.94, issue.1, 2016.
DOI : 10.1080/01621459.1958.10501452

URL : https://hal.archives-ouvertes.fr/hal-01311082

M. Alavi, J. Fernandez-robledo, and G. Vasta, Development of an in Vitro Assay to Examine Intracellular Survival of Perkinsus marinus Trophozoites upon Phagocytosis by Oyster (Crassostrea virginica and Crassostrea ariakensis) Hemocytes, Journal of Parasitology, vol.95, issue.4, pp.900-907, 2009.
DOI : 10.1645/GE-1864.1

A. Alfonso, M. Louzao, M. Vieytes, and L. Botana, Comparative study of the stability of saxitoxin and neosaxitoxin in acidic solutions and lyophilized samples, Toxicon, vol.32, issue.12, pp.1593-1598, 1994.
DOI : 10.1016/0041-0101(94)90318-2

A. D. Alpermann, T. J. , C. A. Collos, Y. Masseret, E. Montresor et al., The globally distributed genus Alexandrium: Multifaceted roles in marine ecosystems and impacts on human health, Harmfull Algae, vol.14, pp.10-35, 2012.

E. Bachere, Y. Gueguen, M. Gonzalez, J. De-lorgeril, J. Garnier et al., Insights into the anti-microbial defense of marine invertebrates: the penaeid shrimps and the oyster Crassostrea gigas, Immunological Reviews, vol.31, issue.1, pp.149-168, 2004.
DOI : 10.1128/AAC.44.11.2925-2931.2000

E. Bachere, R. Rosa, P. Schmitt, A. Poirier, N. Merou et al., The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view, Fish & Shellfish Immunology, vol.46, issue.1, pp.50-64, 2015.
DOI : 10.1016/j.fsi.2015.02.040

URL : https://hal.archives-ouvertes.fr/hal-01162911

M. Bardouil, M. Bohec, S. Bougrier, P. Lassus, and P. Truquet, Feeding responses of Crassostrea gigas (Thunberg) to inclusion of different proportions of toxic dinoflagellates in their diet, Oceanol. Acta, vol.19, pp.177-182, 1996.

V. M. Bricelj and S. E. Shumway, Paralytic Shellfish Toxins in Bivalve Molluscs: Occurrence, Transfer Kinetics, and Biotransformation, Reviews in Fisheries Science, vol.6, issue.4, pp.315-383, 1998.
DOI : 10.1080/10641269891314294

S. Cestele and W. Catterall, Molecular mechanisms of neurotoxin action on voltage-gated sodium channels, Biochimie, vol.82, issue.9-10, pp.9-10, 2000.
DOI : 10.1016/S0300-9084(00)01174-3

K. Cusick, S. Minkin, S. Dodani, C. Chang, S. Wilhelm et al., Inhibition of Copper Uptake in Yeast Reveals the Copper Transporter Ctr1p As a Potential Molecular Target of Saxitoxin, Environmental Science & Technology, vol.46, issue.5, pp.2959-2966, 2012.
DOI : 10.1021/es204027m

C. Detree, G. Nunez-acuana, S. Roberts, and C. Gallardo-escarate, Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations, PLOS ONE, vol.44, issue.2, p.11, 2016.
DOI : 10.1371/journal.pone.0165231.s003

M. Duperthuy, P. Schmitt, E. Garzon, A. Caro, R. Rosa et al., Use of OmpU porins for attachment and invasion of Crassostrea gigas immune cells by the oyster pathogen Vibrio splendidus, Proceedings of the National Academy of Sciences, vol.29, issue.9, 2011.
DOI : 10.1093/nar/29.9.e45

N. Estrada, F. Ascencio, L. Shoshani, and R. Contreras, Apoptosis of hemocytes from lions-paw scallop Nodipecten subnodosus induced with paralyzing shellfish poison from Gymnodinium catenatum, Immunobiology, vol.219, issue.12, pp.964-974, 2014.
DOI : 10.1016/j.imbio.2014.07.006

L. Galluzzi, I. Vitale, J. Abrams, E. Alnemri, E. Baehrecke et al., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, Cell Death and Differentiation, vol.94, issue.1, pp.107-120, 2012.
DOI : 10.1083/jcb.200712051

O. Gervais, R. T. Arzul, and I. , Induction of apoptosis by UV in the flat oyster, Ostrea edulis, Fish & Shellfish Immunology, vol.46, issue.2, pp.232-242, 2015.
DOI : 10.1016/j.fsi.2015.05.046

H. Hegaret, P. Da-silva, G. Wikfors, H. Haberkorn, S. Shumway et al., In vitro interactions between several species of harmful algae and haemocytes of bivalve molluscs, Cell Biology and Toxicology, vol.188, issue.4, pp.249-266, 2011.
DOI : 10.2307/1542308

URL : https://hal.archives-ouvertes.fr/hal-00635820

H. Hegaret, G. Wikfors, and S. Shumway, DIVERSE FEEDING RESPONSES OF FIVE SPECIES OF BIVALVE MOLLUSC WHEN EXPOSED TO THREE SPECIES OF HARMFUL ALGAE, Journal of Shellfish Research, vol.26, issue.2, pp.549-559, 2007.
DOI : 10.2983/0730-8000(2007)26[549:DFROFS]2.0.CO;2

H. Hegaret, G. Wikfors, and P. Soudant, Flow-cytometric analysis of haemocytes from eastern oysters, Crassostrea virginica, subjected to a sudden temperature elevation, Journal of Experimental Marine Biology and Ecology, vol.293, issue.2, pp.237-248, 2003.
DOI : 10.1016/S0022-0981(03)00236-3

F. Hughes, B. Foster, S. Grewal, and I. Sokolova, Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus, Fish & Shellfish Immunology, vol.29, issue.2, pp.247-257, 2010.
DOI : 10.1016/j.fsi.2010.03.003

A. Huvet, D. J. Quere, C. Dubois, S. , P. M. Van-wormhoudt et al., Tissue expression of two ??-amylase genes in the Pacific oyster Crassostrea gigas. Effects of two different food rations, Aquaculture, vol.228, issue.1-4, pp.321-333, 2003.
DOI : 10.1016/S0044-8486(03)00323-5

C. Kao, Pharmacology of tetrodotoxin and saxitoxin, Federation proceedings, vol.31, issue.3, pp.1117-1123, 1972.

J. Landsberg, S. Hall, J. Johannessen, K. White, S. Conrad et al., Saxitoxin Puffer Fish Poisoning in the United States, with the First Report of Pyrodinium bahamense as the Putative Toxin Source, Environmental Health Perspectives, vol.114, issue.10, pp.1502-1507, 2006.
DOI : 10.1289/ehp.8998

M. Lassudrie, P. Soudant, J. Nicolas, P. Miner, L. Grand et al., Exposure to the toxic dinoflagellate Alexandrium catenella modulates juvenile oyster Crassostrea gigas hemocyte variables subjected to different biotic conditions, Fish & Shellfish Immunology, vol.51, pp.104-115, 2016.
DOI : 10.1016/j.fsi.2016.02.017

URL : https://hal.archives-ouvertes.fr/hal-01483232

H. Hegaret, Physiological and pathological changes in the eastern oyster Crassostrea virginica infested with the trematode Bucephalus sp and exposed to the toxic dinoflagellate Alexandrium fundyense, Journal of Invertebrate Pathology, vol.126, pp.51-63, 2015.

L. Llewellyn and E. Moczydlowski, Characterization of Saxitoxin Binding to Saxiphilin, a Relative of the Transferrin Family That Displays pH-Dependent Ligand Binding, Biochemistry, vol.33, issue.40, pp.12312-12322, 1994.
DOI : 10.1021/bi00206a039

D. Mello, P. Da-silva, M. Barracco, P. Soudant, and H. Hegaret, Effects of the dinoflagellate Alexandrium minutum and its toxin (saxitoxin) on the functional activity and gene expression of Crassostrea gigas hemocytes, Harmful Algae, vol.26, pp.45-51, 2013.
DOI : 10.1016/j.hal.2013.03.003

URL : https://hal.archives-ouvertes.fr/hal-00844065

M. Morabito, L. Llewellyn, and E. Moczydlowski, Correction: Molecular Cloning of Bullfrog Saxiphilin: A Unique Relative of the Transferrin Family that Binds Saxitoxin, Proceedings of the National Academy of Sciences, vol.92, issue.14, pp.6651-6651, 1995.
DOI : 10.1073/pnas.92.14.6651

T. Narahashi, Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes, Federation proceedings, vol.31, issue.3, pp.1124-1132, 1972.

Y. Oshima, P. Lassus, G. Arzul, and E. Erard-le-denn, Chemical and enzymatic transformation of paralytic shellfish toxins in marine organisms, 1995.

C. Robb, E. Dyrynda, R. Gray, A. Rossi, and V. Smith, Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon, Nature Communications, vol.5, p.4627, 2014.
DOI : 10.1016/j.dci.2010.12.012

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143918

J. Rolland, K. Pelletier, E. Masseret, F. Rieuvilleneuve, V. Savar et al., Paralytic Toxins Accumulation and Tissue Expression of ??-Amylase and Lipase Genes in the Pacific Oyster Crassostrea gigas Fed with the Neurotoxic Dinoflagellate Alexandrium catenella, Marine Drugs, vol.16, issue.12, pp.2519-2534, 2012.
DOI : 10.1006/meth.2001.1262

I. Sokolova, Apoptosis in molluscan immune defense, Isj-Invertebrate Survival Journal, vol.6, issue.1, pp.49-58, 2009.

I. Sokolova, S. Evans, and F. Hughes, Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition, Journal of Experimental Biology, vol.207, issue.19, pp.3369-3380, 2004.
DOI : 10.1242/jeb.01152

K. Terahara and K. Takahashi, Mechanisms and Immunological Roles of Apoptosis in Molluscs, Current Pharmaceutical Design, vol.14, issue.2, pp.131-137, 2008.
DOI : 10.2174/138161208783378725

K. Terahara, K. Takahashi, A. Nakamura, M. Osada, M. Yoda et al., Differences in integrin-dependent phagocytosis among three hemocyte subpopulations of the Pacific oyster ???Crassostrea gigas???, Developmental & Comparative Immunology, vol.30, issue.8, pp.667-683, 2006.
DOI : 10.1016/j.dci.2005.09.009

N. Touzet, J. Franco, R. , and R. , spp. in Irish coastal waters, African Journal of Marine Science, vol.28, issue.2, pp.181-184, 2006.
DOI : 10.2989/18142320609504144

A. Vanhove, T. Rubio, N. Ann, A. Lemir, and D. Roche, Copper homeostasis at the host vibrio interface: lessons from intracellular vibrio transcriptomics, Environmental Microbiology, vol.18, issue.3, pp.875-888, 2016.
DOI : 10.1111/1462-2920.13078

URL : https://hal.archives-ouvertes.fr/hal-01311061

J. Wang, J. Salata, and P. Bennett, Channels, The Journal of General Physiology, vol.66, issue.6, pp.583-598, 2003.
DOI : 10.1021/ja00755a052

URL : https://hal.archives-ouvertes.fr/inria-00535881

M. Wiese, D. Agostino, P. Mihali, T. Moffitt, M. Neilan et al., Neurotoxic Alkaloids: Saxitoxin and Its Analogs, Marine Drugs, vol.32, issue.7, pp.2185-2211, 2010.
DOI : 10.1179/174313209X380829

URL : http://doi.org/10.3390/md8072185

G. Zhang, V. Gurtu, S. Martin, and S. Kain, Redistribution of plasma membrane phosphatidylserine occurs during an early stage of apoptosis, Molecular Biology of the Cell, vol.7, pp.1109-1109, 1996.

L. Zhang, L. Li, and G. Zhang, Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system, Developmental & Comparative Immunology, vol.35, issue.5, pp.603-610, 2011.
DOI : 10.1016/j.dci.2011.01.005