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Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Angeline Nemeth 1 Lucy Di Marco 1, 2 Florent Boutitie 3 Michael Sdika 4, 5 Denis Grenier 1, 6 Muriel Rabilloud 3 Olivier Beuf 1 Jean-Baptiste Pialat 7
1 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2 Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon)
3 Biostatistiques santé
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
4 Images et Modèles
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
5 Service Informatique et développements
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
6 PILoT - Plateforme d'Imagerie Multimodale LyonTech
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
7 LYOS - Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases
Abstract : PurposeTo assess the T1ρ and T2 values in the hip cartilage of healthy volunteers and to evaluate the reproducibility of these measurements.Materials and MethodsThe right hip joint of 30 asymptomatic volunteers was explored with 3T magnetic resonance imaging (MRI). Quantitative 3D T1ρ- and T2-maps sequences were repeated twice with a 30-minute delay (immediate reproducibility). The same protocol was repeated 14 days later (short-term reproducibility). Immediate and short-term reproducibility were estimated using coefficients of variation and correlation concordance coefficients (CCC). The precisions of the measurements were estimated by the ratio of the standard deviations. A mixed linear model was used to analyze the effect of patient's characteristics on T1ρ and T2 values.ResultsImmediate reproducibility was significantly better than short-term reproducibility for T1ρ (CCC of 0.75 versus 0.55; P = 0.007) and T2 (CCC 0.65 versus 0.32; P < 0.001). The precisions of the measurements were estimated between 5.5% and 9.1%. Median T1ρ values were 6.0 msec higher in women than in men (P = 0.006), with no significant influence of age, body mass index (BMI), or sports activity. Median T2 values were not significantly different between men and women (0.4 msec lower in women; P = 0.76). There was no significant influence of age, BMI, or sports activity. T1ρ and T2 values were lower in lateral regions than in medial regions (4.9 msec and 2.5 msec lower respectively; P < 0.0001).ConclusionImmediate reproducibility of T1ρ and T2 values is better than short-term, with limited effect of 30 minutes decubitus. T1ρ values are significantly higher in women.Level of Evidence: 2Technical Efficacy: Stage 2
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Journal articles
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https://hal.archives-ouvertes.fr/hal-01560104
Contributor : Béatrice Rayet Connect in order to contact the contributor
Submitted on : Tuesday, July 11, 2017 - 11:32:46 AM
Last modification on : Thursday, July 22, 2021 - 3:47:35 AM

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PRIMES_WP2 | PRIMES | CNRS | HCL | CREATIS | BIOENVIS | INSA-LYON | UNIV-LYON1 | UNIV-ST-ETIENNE | INSA-GROUPE | UDL | INRIA

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Angeline Nemeth, Lucy Di Marco, Florent Boutitie, Michael Sdika, Denis Grenier, et al.. Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers. Journal of Magnetic Resonance Imaging, Wiley-Blackwell, 2017, 47 (4), pp.1022-1033. ⟨10.1002/jmri.25799⟩. ⟨hal-01560104⟩

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