Think Negative: Finding the Best Electrospray Ionization/MS Mode for Your Analyte

Abstract : For the first time, the electrospray ionization efficiency (IE) scales in positive and negative mode are united into a single system enabling,direct comparison of IE values across ionization modes. This is made possible by the use of a reference Compound that ionizes to a similar extent in both positive, and negative modes. Thus, choosing the optimal (i.e., most sensitive) ionization conditions for a given set of analytes is enabled. Ionizatiori efficiencies of 33 compounds ionizing in both modes demonstrate that, contrary to general practice, negative mode allows, better sensitivity for 46% of such compounds Whereas the positive mode is preferred for only 18%, and for 36%, the results for both modes are comparable.
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Submitted on : Friday, June 23, 2017 - 4:45:50 PM
Last modification on : Thursday, November 29, 2018 - 11:52:06 AM

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Piia Liigand, Karl Kaupmees, Kristjan Haav, Jaanus Liigand, Ivo Leito, et al.. Think Negative: Finding the Best Electrospray Ionization/MS Mode for Your Analyte. Analytical Chemistry, American Chemical Society, 2017, 89 (11), pp.5665-5668. ⟨10.1021/acs.analchem.7b00096⟩. ⟨hal-01546359⟩

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