P. Carmeliet, Angiogenesis in life, disease and medicine, Nature, vol.Teill II, issue.7070, pp.932-936, 2005.
DOI : 10.1038/nature04478

N. Ferrara, The role of VEGF in the regulation of physiological and pathological angiogenesis, EXS, vol.94, pp.209-231, 2005.
DOI : 10.1007/3-7643-7311-3_15

N. Ferrara, Role of vascular endothelial growth factor in the regulation of angiogenesis, Kidney International, vol.56, issue.3, pp.794-814, 1999.
DOI : 10.1046/j.1523-1755.1999.00610.x

N. Ferrara, VEGF and the quest for tumour angiogenesis factors, Nature Reviews Cancer, vol.120, issue.10, pp.795-803, 2002.
DOI : 10.1038/nrc909

J. Folkman, Angiogenesis in cancer, vascular, rheumatoid and other disease, Nature Medicine, vol.326, issue.1, pp.27-31, 1995.
DOI : 10.1038/359845a0

P. Carmeliet, V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens et al., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele, Nature, vol.380, issue.6573, pp.435-439, 1996.
DOI : 10.1038/380435a0

N. Ferrara, K. Carver-moore, H. Chen, M. Dowd, L. Lu et al., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene, Nature, vol.380, issue.6573, pp.439-442, 1996.
DOI : 10.1038/380439a0

L. Miquerol, B. L. Langille, and A. Nagy, Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression, Development, vol.127, pp.3941-3946, 2000.

N. Ferrara, Vascular Endothelial Growth Factor: Basic Science and Clinical Progress, Endocrine Reviews, vol.25, issue.4, pp.581-611, 2004.
DOI : 10.1210/er.2003-0027

J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung et al., Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1., Molecular and Cellular Biology, vol.16, issue.9, pp.4604-4613, 1996.
DOI : 10.1128/MCB.16.9.4604

A. P. Levy, N. S. Levy, O. Iliopoulos, C. Jiang, W. G. Kaplin et al., Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene, Kidney International, vol.51, issue.2, pp.575-578, 1997.
DOI : 10.1038/ki.1997.82

J. Milanini, F. Vinals, J. Pouyssegur, and G. Pages, p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts, Journal of Biological Chemistry, vol.273, issue.29, pp.18165-18172, 1998.
DOI : 10.1074/jbc.273.29.18165

G. Pages and J. Pouyssegur, Transcriptional regulation of the Vascular Endothelial Growth Factor gene?a concert of activating factors, Cardiovascular Research, vol.65, issue.3, pp.564-573, 2005.
DOI : 10.1016/j.cardiores.2004.09.032
URL : https://hal.archives-ouvertes.fr/hal-00321947

N. Ferrara, H. P. Gerber, and J. Lecouter, The biology of VEGF and its receptors, Nature Medicine, vol.9, issue.6, pp.669-676, 2003.
DOI : 10.1038/nm0603-669

G. Akiri, D. Nahari, Y. Finkelstein, S. Y. Le, O. Elroy-stein et al., Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription, Oncogene, vol.17, issue.2, pp.227-236, 1998.
DOI : 10.1038/sj.onc.1202019

D. O. Bates, T. G. Cui, J. M. Doughty, M. Winkler, M. Sugiono et al., VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma, Cancer Res, vol.62, pp.4123-4131, 2002.

K. A. Houck, N. Ferrara, J. Winer, G. Cachianes, B. Li et al., The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA, Molecular Endocrinology, vol.5, issue.12, pp.1806-1814, 1991.
DOI : 10.1210/mend-5-12-1806

L. Jingjing, Y. Xue, N. Agarwal, and R. S. Roque, Human Muller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor, Invest. Ophthalmol. Vis. Sci, vol.40, pp.752-759, 1999.

T. Lange, N. Guttmann-raviv, L. Baruch, M. Machluf, and G. Neufeld, VEGF162, A New Heparin-binding Vascular Endothelial Growth Factor Splice Form That Is Expressed in Transformed Human Cells, Journal of Biological Chemistry, vol.278, issue.19, pp.17164-17169, 2003.
DOI : 10.1074/jbc.M212224200

Z. Poltorak, T. Cohen, R. Sivan, Y. Kandelis, G. Spira et al., VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix, Journal of Biological Chemistry, vol.272, issue.11, pp.7151-7158, 1997.
DOI : 10.1074/jbc.272.11.7151

E. Tischer, R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz et al., The human gene for vascular 2444 endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing, Nucleic Acids Research J. Biol. Chem, vol.36, issue.266, pp.11947-11954, 1991.

C. Whittle, K. Gillespie, R. Harrison, P. W. Mathieson, and S. J. Harper, Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant, Clinical Science, vol.97, issue.3, pp.303-312, 1999.
DOI : 10.1042/cs0970303

K. A. Houck, D. W. Leung, A. M. Rowland, J. Winer, and N. Ferrara, Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms, J. Biol. Chem, vol.267, pp.26031-26037, 1992.

J. Grunstein, J. J. Masbad, R. Hickey, F. Giordano, and R. S. Johnson, Isoforms of Vascular Endothelial Growth Factor Act in a Coordinate Fashion To Recruit and Expand Tumor Vasculature, Molecular and Cellular Biology, vol.20, issue.19, pp.7282-7291, 2000.
DOI : 10.1128/MCB.20.19.7282-7291.2000

I. Huez, S. Bornes, D. Bresson, L. Creancier, and H. Prats, New Vascular Endothelial Growth Factor Isoform Generated by Internal Ribosome Entry Site-Driven CUG Translation Initiation, Molecular Endocrinology, vol.15, issue.12, pp.2197-2210, 2001.
DOI : 10.1210/mend.15.12.0738

M. Meiron, R. Anunu, E. J. Scheinman, S. Hashmueli, and B. Z. Levi, New Isoforms of VEGF Are Translated from Alternative Initiation CUG Codons Located in Its 5???UTR, Biochemical and Biophysical Research Communications, vol.282, issue.4, pp.1053-1060, 2001.
DOI : 10.1006/bbrc.2001.4684

M. K. Tee and R. B. Jaffe, A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon, Biochemical Journal, vol.359, issue.1, pp.219-226, 2001.
DOI : 10.1042/bj3590219

I. Huez, L. Creancier, S. Audigier, M. C. Gensac, A. C. Prats et al., Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA, Molecular and Cellular Biology, vol.18, issue.11, pp.6178-6190, 1998.
DOI : 10.1128/MCB.18.11.6178

D. L. Miller, J. A. Dibbens, A. Damert, W. Risau, M. A. Vadas et al., The vascular endothelial growth factor mRNA contains an internal ribosome entry site, FEBS Letters, vol.277, issue.3, pp.417-420, 1998.
DOI : 10.1016/S0014-5793(98)01025-4

S. Bornes, L. Prado-lourenco, A. Bastide, C. Zanibellato, J. S. Iacovoni et al., Translational Induction of VEGF Internal Ribosome Entry Site Elements During the Early Response to Ischemic Stress, Circulation Research, vol.100, issue.3, pp.305-308, 2007.
DOI : 10.1161/01.RES.0000258873.08041.c9
URL : https://hal.archives-ouvertes.fr/inserm-00409540

Y. Rosenbaum-dekel, A. Fuchs, E. Yakirevich, A. Azriel, S. Mazareb et al., Nuclear localization of long-VEGF is associated with hypoxia and tumor angiogenesis, Biochemical and Biophysical Research Communications, vol.332, issue.1, pp.271-278, 2005.
DOI : 10.1016/j.bbrc.2005.04.123

N. S. Levy, M. A. Goldberg, and A. P. Levy, Sequencing of the human vascular endothelial growth factor (VEGF) 3??? untranslated region (UTR): conservation of five hypoxia-inducible RNA-protein binding sites, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1352, issue.2, pp.1352-167, 1997.
DOI : 10.1016/S0167-4781(97)00052-3

J. A. Dibbens, D. L. Miller, A. Damert, W. Risau, M. A. Vadas et al., Hypoxic Regulation of Vascular Endothelial Growth Factor mRNA Stability Requires the Cooperation of Multiple RNA Elements, Molecular Biology of the Cell, vol.10, issue.4, pp.907-919, 1999.
DOI : 10.1091/mbc.10.4.907

K. P. Claffey, S. C. Shih, A. Mullen, S. Dziennis, J. L. Cusick et al., Identification of a Human VPF/VEGF 3' Untranslated Region Mediating Hypoxia-induced mRNA Stability, Molecular Biology of the Cell, vol.9, issue.2, pp.469-481, 1998.
DOI : 10.1091/mbc.9.2.469

N. S. Levy, S. Chung, H. Furneaux, and A. P. Levy, Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR, Journal of Biological Chemistry, vol.273, issue.11, pp.6417-6423, 1998.
DOI : 10.1074/jbc.273.11.6417

C. Onesto, E. Berra, R. Grepin, and G. Pages, Poly(A)-binding Protein-interacting Protein 2, a Strong Regulator of Vascular Endothelial Growth Factor mRNA, Journal of Biological Chemistry, vol.279, issue.33, pp.34217-34226, 2004.
DOI : 10.1074/jbc.M400219200
URL : https://hal.archives-ouvertes.fr/hal-00323613

S. C. Shih, A. Mullen, K. Abrams, D. Mukhopadhyay, and K. P. Claffey, Role of Protein Kinase C Isoforms in Phorbol Ester-induced Vascular Endothelial Growth Factor Expression in Human Glioblastoma Cells, Journal of Biological Chemistry, vol.274, issue.22, pp.15407-15414, 1999.
DOI : 10.1074/jbc.274.22.15407

D. Ciais, N. Cherradi, S. Bailly, E. Grenier, E. Berra et al., Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b, Oncogene, vol.23, issue.53, pp.8673-8680, 2004.
DOI : 10.1038/sj.onc.1207939
URL : https://hal.archives-ouvertes.fr/hal-00322368

L. S. Coles, M. A. Bartley, A. Bert, J. Hunter, S. Polyak et al., A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization, European Journal of Biochemistry, vol.8, issue.3, pp.648-660, 2004.
DOI : 10.1242/jcs.00353

S. Bornes, M. Boulard, C. Hieblot, C. Zanibellato, J. S. Iacovoni et al., Control of the Vascular Endothelial Growth Factor Internal Ribosome Entry Site (IRES) Activity and Translation Initiation by Alternatively Spliced Coding Sequences, Journal of Biological Chemistry, vol.279, issue.18, pp.18717-18726, 2004.
DOI : 10.1074/jbc.M308410200

F. Armstrong, L. Lamant, C. Hieblot, G. Delsol, and C. Touriol, TPM3-ALK expression induces changes in cytoskeleton organisation and confers higher metastatic capacities than other ALK fusion proteins, European Journal of Cancer, vol.43, issue.4, pp.640-646, 2007.
DOI : 10.1016/j.ejca.2006.12.005

C. Touriol, M. Roussigne, M. C. Gensac, H. Prats, and A. C. Prats, Alternative Translation Initiation of Human Fibroblast Growth Factor 2 mRNA Controlled by Its 3'-Untranslated Region Involves a Poly(A) Switch and a Translational Enhancer, Journal of Biological Chemistry, vol.275, issue.25, pp.19361-19367, 2000.
DOI : 10.1074/jbc.M908431199

F. Armstrong, M. M. Duplantier, P. Trempat, C. Hieblot, L. Lamant et al., Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells, Oncogene, vol.23, issue.36, pp.6071-6082, 2004.
DOI : 10.1038/sj.onc.1207813

N. Sonenberg, mRNA translation: influence of the 5??? and 3??? untranslated regions, Current Opinion in Genetics & Development, vol.4, issue.2, pp.310-315, 1994.
DOI : 10.1016/S0959-437X(05)80059-0

P. Carmeliet, Angiogenesis in health and disease, Nature Medicine, vol.9, issue.6, pp.653-660, 2003.
DOI : 10.1038/nm0603-653

D. Lambrechts, E. Storkebaum, M. Morimoto, J. Del-favero, F. Desmet et al., VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death, Nature Genetics, vol.34, issue.4, pp.383-394, 2003.
DOI : 10.1038/ng1211

M. Kozak, Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes., Molecular and Cellular Biology, vol.7, issue.10, pp.3438-3445, 1987.
DOI : 10.1128/MCB.7.10.3438

A. Mehta, C. R. Trotta, and S. W. Peltz, Derepression of the Her-2 uORF is mediated by a novel post-transcriptional control mechanism in cancer cells, Genes & Development, vol.20, issue.8, pp.939-953, 2006.
DOI : 10.1101/gad.1388706

I. Yaman, J. Fernandez, H. Liu, M. Caprara, A. A. Komar et al., The Zipper Model of Translational Control, Cell, vol.113, issue.4, pp.519-531, 2003.
DOI : 10.1016/S0092-8674(03)00345-3

S. M. Lewis and M. Holcik, For IRES trans-acting factors, it is all about location, Oncogene, vol.27, issue.8, pp.1033-1035, 2007.
DOI : 10.1038/sj.cdd.4401642

A. C. Prats and H. Prats, Translational control of gene expression: Role of IRESs and consequences for cell transformation and angiogenesis, Prog. Nucleic Acid Res. Mol. Biol, vol.72, pp.367-413, 2002.
DOI : 10.1016/S0079-6603(02)72075-8

H. T. Zhang, P. A. Scott, L. Morbidelli, S. Peak, J. Moore et al., The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo, Br. J. Cancer, vol.83, pp.63-68, 2000.

R. Catena, V. Muniz-medina, B. Moralejo, B. Javierre, C. J. Best et al., Increased expression of VEGF121/VEGF165-189 ratio results in a significant enhancement of human prostate tumor angiogenesis, International Journal of Cancer, vol.99, issue.Suppl 3, pp.2096-2109, 2007.
DOI : 10.1002/ijc.22461