New insights into the classification and nomenclature of cortical GABAergic interneurons

Bruno Cauli (1) , Alfonso Fairen , Dirk Feldmeyer , Gord Fishell , David Fitzpatrick , Tamas F. Freund , Guillermo Gonzalez-Burgos , Shaul Hestrin , Sean Hill , Patrick R. Hof , Josh Huang , Edward G. Jones , Yasuo Kawaguchi , Zoltan Kisvarday , Yoshiyuki Kubota , David A. Lewis , Oscar Marin , Henry Markram , Chris J. Mcbain , Hanno S. Meyer , Hannah Monyer , Sacha B. Nelson , Kathleen Rockland , Jean Rossier , John L. R. Rubenstein , Bernardo Rudy , Massimo Scanziani , Gordon M. Shepherd , Chet C. Sherwood , Jochen F. Staiger , Gabor Tamas , Alex Thomson , Yun Wang , Rafael Yuste , Giorgio A. Ascoli , Javier Defelipe , Pedro L. Lopez-Cruz , Ruth Benavides-Piccione , Concha Bielza , Pedro Larranaga , Stewart Anderson , Andreas Burkhalter

1 NPS-03 - Réseau cortical et couplage neurovasculaire = Cortical Network and Neurovascular

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

Domaines: Neurosciences [q-bio.NC]

Bruno Cauli, Alfonso Fairen, Dirk Feldmeyer, Gord Fishell, David Fitzpatrick, et al.. New insights into the classification and nomenclature of cortical GABAergic interneurons. Nature Reviews Neuroscience, 2013, 14 (3), pp.202-216. ⟨10.1038/nrn3444⟩. ⟨hal-01541368⟩