Advances in the synthesis of α‑quaternary α‑ethynyl α‑amino acids

Abstract : α-Quaternary α-ethynyl α-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of α-quaternary α-ethynyl α-amino acids covering the period from 1977 to 2015.
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Thibaut Boibessot, David Bénimélis, Patrick Meffre, Zohra Benfodda. Advances in the synthesis of α‑quaternary α‑ethynyl α‑amino acids. Amino Acids, Springer Verlag, 2016, 48 (9), pp.2081-2101. ⟨10.1007/s00726-016-2276-2⟩. ⟨hal-01540958⟩

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