Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.

Résumé : MSA is a fatal neurodegenerative disorder characterized by a combination of autonomic dysfunction, cerebellar ataxia, and l-dopa unresponsive parkinsonism. The hallmark of MSA is the accumulation of α-synuclein, forming cytoplasmic inclusions in oligodendrocytes. Adeno-associated viruses allow efficient targeting of disease-associated genes in selected cellular ensembles and have proven efficient for the neuronal overexpression of α-synuclein in the substantia nigra in the context of PD.
Type de document :
Article dans une revue
Movement Disorders, Wiley, 2017, 〈10.1002/mds.27041〉
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01537940
Contributeur : Chantal Guerin <>
Soumis le : mardi 13 juin 2017 - 11:03:04
Dernière modification le : jeudi 11 janvier 2018 - 06:25:42

Identifiants

Collections

Citation

Fares Bassil, Paul A Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, et al.. Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.. Movement Disorders, Wiley, 2017, 〈10.1002/mds.27041〉. 〈hal-01537940〉

Partager

Métriques

Consultations de la notice

94