Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.

Abstract : MSA is a fatal neurodegenerative disorder characterized by a combination of autonomic dysfunction, cerebellar ataxia, and l-dopa unresponsive parkinsonism. The hallmark of MSA is the accumulation of α-synuclein, forming cytoplasmic inclusions in oligodendrocytes. Adeno-associated viruses allow efficient targeting of disease-associated genes in selected cellular ensembles and have proven efficient for the neuronal overexpression of α-synuclein in the substantia nigra in the context of PD.
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https://hal.archives-ouvertes.fr/hal-01537940
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Submitted on : Tuesday, June 13, 2017 - 11:03:04 AM
Last modification on : Thursday, January 11, 2018 - 6:25:42 AM

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Fares Bassil, Paul A Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, et al.. Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.. Movement Disorders, Wiley, 2017, ⟨10.1002/mds.27041⟩. ⟨hal-01537940⟩

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