Deciphering gene sets annotations with ontology based visualization

Abstract : Nowadays, one of the main challenges in biology is to make use of several sources of data to improve our understanding of life. When analyzing experimental data, researchers aim at clustering genes that show a similar behavior through specific external conditions. Thus, the functional interpretation of genes is crucial and involves making use of the whole subset of terms that annotate these genes and which can be relatively large and redundant. The manual expertise to clearly decipher the main functions that may be related to the gene set is time-consuming and becomes impracticable when the number of gene sets increases, like in the case of vaccine/drug trials. To overcome this drawback, it may be necessary to reduce the dataset with the aim to apply visualization approaches. In this paper, we propose a new pipeline combining enrichment and annotation terms simplification to produce a synthetic visualization of several gene sets simultaneously. We illustrate the efficiency of our method on a case study aiming at analyzing the immune response in diseases.
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Conference papers
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https://hal.archives-ouvertes.fr/hal-01524572
Contributor : Aarón Ayllón-Benítez <>
Submitted on : Thursday, May 18, 2017 - 2:05:56 PM
Last modification on : Thursday, November 29, 2018 - 9:56:01 AM

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  • HAL Id : hal-01524572, version 1

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Aarón Ayllón-Benítez, Fleur Mougin, Jesualdo Tomás Fernández-Breis, Manuel Quesada Martinez, Patricia Thebault, et al.. Deciphering gene sets annotations with ontology based visualization. 21 st International conference information visualisation, Jul 2017, London, United Kingdom. ⟨hal-01524572⟩

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