Differential Transcriptional Response To Staphylococcus aureus Infection In Two Divergent Lines Of Sheep Selected On Milk Somatic Cell Score

Cécile Bonnefont (1, 2) , Gilles Foucras (2) , Mehdi Toufeer (2) , Cécile Caubet (2) , Marie-Rose Aurel (2) , Christèle Robert-Granié (3) , Patricia Cunha (1) , Florence B. Gilbert (4) , Pascal Rainard (4) , Rachel Rupp (4)

1 SAGA - Station d'Amélioration Génétique des Animaux
2 IHAP - Interactions hôtes-agents pathogènes [Toulouse]
3 LA FAGE - Domaine expérimental de La Fage
4 UR IASP - Infectiologie Animale et Santé Publique

The milk somatic cell score (SCS) is an indirect indicator of mastitis, currently used as a selection criterion of dairy ruminants that leads to decreased intra-mammary infection prevalence. In the present study, gene expression profiles after Staphylococcus stimulations were determined in three cell types of mastitis resistant and susceptible ewes. The comparisons of the lists of the differentially-expressed genes allowed identification of commonly-regulated genes among cell types. These results lead to identify a subset of genes involved in pathogen-related receptor signaling. These genes may play an important role in recognition of pathogens and may improve resistance to intramammary infections.

Mots clés: Mastitis; Staphylococcus; Milk; Somatic cell score- Sheep; Microarray; Infectious diseases; Ruminants; Aureus; SCS; Transcritomic; Resistance

Domaines: Médecine vétérinaire et santé animale; Santé

Cécile Bonnefont, Gilles Foucras, Mehdi Toufeer, Cécile Caubet, Marie-Rose Aurel, et al.. Differential Transcriptional Response To Staphylococcus aureus Infection In Two Divergent Lines Of Sheep Selected On Milk Somatic Cell Score. 9th World Congress on Genetics Applied to Livestock Production, Aug 2010, Leipzig, Germany. pp.1-4. ⟨hal-01521770⟩