ESHAP chemotherapy is efficient in refractory/relapsed primary central nervous system lymphoma: report of four cases. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue OncoTargets and Therapy Année : 2015

ESHAP chemotherapy is efficient in refractory/relapsed primary central nervous system lymphoma: report of four cases.

Résumé

Primary central nervous system non-Hodgkin's lymphoma is a rare presentation, almost always of diffuse large B-cell type. Although there is no consensus regarding therapy for this condition, induction regimens are based on high-dose methotrexate and consolidation whole-brain radiotherapy, or, more preferred recently, blood-brain barrier penetrating drugs such as etoposide, cytarabine, and alkylating agents like temozolomide, ifosfamide, and lomustine. We present here four cases of relapsed/refractory primary central nervous system lymphoma treated with ESHAP (etoposide, solumedrol, high-dose cytarabine, and platinum) chemotherapy to complete remission, with the eligible patients proceeding to autologous transplantation. We want to draw attention to this interesting, relatively well tolerated, underused therapeutic option, in a setting where treatment options are scarce and evidence-based recommendations are lacking.

Domaines

Immunologie
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Dates et versions

hal-01515354 , version 1 (27-04-2017)

Identifiants

  • HAL Id : hal-01515354 , version 1
  • PUBMED : 26491351

Citer

Rodica Ungur, Adrian Tempescul, Christian Berthou, Cristina Bagacean, Doinel Radeanu, et al.. ESHAP chemotherapy is efficient in refractory/relapsed primary central nervous system lymphoma: report of four cases.. OncoTargets and Therapy, 2015, pp.2771-3. ⟨hal-01515354⟩
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