CELL-DEGRADATION OF CALCIUM PHOSPHATE CERAMICS

Patrick Frayssinet (1) , Nicole Rouquet (1) , Francis Tourenne (1) , Jacques Fages (1) , D. Hardy (2) , Gilbert Bonel (1)

1 Bioland
2 Service de Chirurgie Orthopédique

Calcium phosphate ceramics are used in bone surgery under different forms: dense or porous ceramics as bone substitute, thin ceramic coatings on metallic implants as an osseointegration enhancer. Their degradation depends on their physico-chemical composition. Natural calcium phosphates of bone are degraded by mononuclear or multinuclear cells and the extracellular matrix induces the differentiation of the degrading cells. Hydroxyapatite, which is one of the most used calcium phosphates, is known as low degradation material. However, the histological analysis of implanted HA-materials both in animals and in humans showed that a cellular degradation took place on the surface of the material.

Mots clés: Dissolution; Remodelling; Macrophage; Calcium phosphate ceramics; Hydroxyapatite; Hydroxyapatite-coatings; Macroporous ceramics; Cell degradation; Osteoclasts

Domaines: Biomatériaux; Anatomie, Histologie, Anatomopathologie [q-bio.TO]

Patrick Frayssinet, Nicole Rouquet, Francis Tourenne, Jacques Fages, D. Hardy, et al.. CELL-DEGRADATION OF CALCIUM PHOSPHATE CERAMICS. CELLS AND MATERIALS, 1993, 3 (4), pp.383-394. ⟨hal-01508687⟩