Assessment of atrioventricular valve regurgitation using biomechanical cardiac modeling

Radomir Chabiniok (1, 2, 3) , Philippe Moireau (2, 3) , Christoph Kiesewetter (1) , Tarique Hussain (4) , Reza Razavi (1) , Dominique Chapelle (2, 3)

1 Imaging Sciences and Biomedical Engineering Division [London]
2 M3DISIM - Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine
3 Université Paris-Saclay
4 University of Texas Southwestern Medical Center [Dallas]

In this work we introduce the modeling of atrioventricular valve regurgitation in a spatially reduced order biomechanical heart model. The model can be fast calibrated using non-invasive data of cardiac magnetic resonance imaging and provides an objective measure of contractile properties of the myocardium in the volume overloaded ven-tricle, for which the real systolic function may be masked by the significant level of the atrioventricular valve regurgitation. After demonstrating such diagnostic capabilities, we show the potential of modeling to address some clinical questions concerning possible therapeutic interventions for specific patients. The fast running of the model allows targeting specific questions of referring clinicians in a clinically acceptable time.

Mots clés: cardiac modeling; atrioventricular regurgitation; therapy planning; reduced-order model; model-based diagnosis assistance

Domaines: Ingénierie biomédicale; Imagerie

Radomir Chabiniok, Philippe Moireau, Christoph Kiesewetter, Tarique Hussain, Reza Razavi, et al.. Assessment of atrioventricular valve regurgitation using biomechanical cardiac modeling. FIMH 2017 - 9th international conference on Functional Imaging and Modeling of the Heart., Pop M and Wright G, Jun 2017, Toronto, Canada. pp.401-411. ⟨hal-01505834⟩