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Article Dans Une Revue Tetrahedron Année : 2013

Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions

Résumé

In positron emission tomog. [11C] PIB, Pittsburgh Compd.- B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the prepn. of the precursor of [11C] PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1- step synthesis of the precursor of [11C] PIB through a Suzuki- Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2- arylbenzothiazole and 2- pyridinylbenzothiazole compds. including [18F] precursor derivs. of PIB contg. a nitro function
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hal-01505055 , version 1 (10-04-2017)

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Guillaume Bort, Maité Sylla-Iyarreta, Clotilde Ferroud. Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions. Tetrahedron, 2013, 69 (35), pp.7345 - 7353. ⟨10.1016/j.tet.2013.06.085⟩. ⟨hal-01505055⟩
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