Comparative Biology of the Resistance to Vitamin K Antagonists: An Overview of the Resistance Mechanisms

Sébastien Lefebvre (1) , Etienne Benoit (1) , Virginie Lattard (1)

1 RS2GP - Rongeurs Sauvages, Risques Sanitaires et Gestion des Populations - UR 1233

Vitamin K antagonists (VKA) are used in human medicine as well as for the manage‐ ment of rodent populations. In both cases, we have to deal with inter-individual resistances. Many mechanisms of resistances are common in humans and rodents. Moreover, with the large use of vitamin K antagonist rodenticides, the resistant phenotype is overrepresented in some rodent populations. Consequently, some resistance mechanisms with a low prevalence in the human population have a higher prevalence in rodent population; thus, they can be more studied in rodents. The aim of this chapter is to cross knowledge coming from human medicine and rodent research in order to better understand each resistance mechanism. After an overview of the essential knowledge for the understanding of the VKA action, this chapter presents the different methods of VKA resistance studying and then it assesses the current knowledge on VKA resistance in humans and rodents.

Mots clés: Anticoagulant agents; Rodenticide selectivity; Rodenticide anticoagulant; Rattus genome; Clotting assay; vitamin K antagonists; Clotting; warfarin; pharmacogenomics; comparative biology; Anticoagulants/adverse effects/therapeutic use

Domaines: Alimentation et Nutrition; Médecine vétérinaire et santé animale; Biochimie [q-bio.BM]; Ecotoxicologie; Toxicologie et chaîne alimentaire

Sébastien Lefebvre, Etienne Benoit, Virginie Lattard. Comparative Biology of the Resistance to Vitamin K Antagonists: An Overview of the Resistance Mechanisms. Basaran Ozcan; Biteker Murat. Anticoagulation Therapy, Intech Open, 2016, 978-953-51-2667-6. ⟨10.5772/64204⟩. ⟨hal-01503402⟩