# Estimating the division rate and kernel in the fragmentation equation

1 MAMBA - Modelling and Analysis for Medical and Biological Applications
Inria de Paris, LJLL - Laboratoire Jacques-Louis Lions
Abstract : We consider the fragmentation equation $\dfrac{\partial}{\partial t}f (t, x) = −B(x)f (t, x) + \int_{ y=x}^{ y=\infty} k(y, x)B(y)f (t, y)dy,$ and address the question of estimating the fragmentation parameters-i.e. the division rate $B(x)$ and the fragmentation kernel $k(y, x)$-from measurements of the size distribution $f (t, ·)$ at various times. This is a natural question for any application where the sizes of the particles are measured experimentally whereas the fragmentation rates are unknown, see for instance (Xue, Radford, Biophys. Journal, 2013) for amyloid fibril breakage. Under the assumption of a polynomial division rate $B(x) = \alpha x^{\gamma}$ and a self-similar fragmentation kernel $k(y, x) = \frac{1}{y} k_0 (x/ y)$, we use the asymptotic behaviour proved in (Escobedo, Mischler, Rodriguez-Ricard, Ann. IHP, 2004) to obtain uniqueness of the triplet $(\alpha, \gamma, k _0)$ and a representation formula for $k_0$. To invert this formula, one of the delicate points is to prove that the Mellin transform of the asymptotic profile never vanishes, what we do through the use of the Cauchy integral.
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https://hal.archives-ouvertes.fr/hal-01501811
Contributor : Marie Doumic <>
Submitted on : Tuesday, April 24, 2018 - 10:02:42 AM
Last modification on : Tuesday, May 14, 2019 - 10:27:02 AM
Long-term archiving on : Tuesday, September 18, 2018 - 10:03:58 PM

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### Citation

Marie Doumic, Miguel Escobedo, Magali Tournus. Estimating the division rate and kernel in the fragmentation equation. Annales de l'Institut Henri Poincaré (C) Non Linear Analysis, Elsevier, 2018, 35 (7), pp.1847-1884. ⟨10.1016/j.anihpc.2018.03.004⟩. ⟨hal-01501811v2⟩

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