Prevalence and specificity of Baeyer–Villiger monooxygenases in fungi

Lorena Butinar (1) , Martina Mohorčič (1) , Valérie Deyris (2) , Katia Duquesne (2) , Gilles Iacazio (2) , Magalie Claeys-Bruno (3) , Josepha Friedrich (1) , Véronique Alphand (2)

1 KI - National Institute of Chemistry [Llubljana]
2 ISM2 - Institut des Sciences Moléculaires de Marseille
3 LISA - Laboratoire d'Instrumentation et Sciences Analytiques

Out of 107 fungal strains belonging to three phyla (Ascomycota, Basidiomycota and Zygomycota) and 46 genera, 86 exhibited Baeyer–Villiger Monooxygenase (BVMO) activity against racemic bicyclo[3.2.0]hep-tenone. The strains were classified into three ‘‘profiles’’ based on regio- and enantioselectivity. Statistical analyses of our results, extended by literature data, showed that these profiles could be related to the taxonomic classification of the strains, and suggest that the BVMOs from the Zygomycota phylum may be different in their primary structures from established ones.

Domaines: Sciences du Vivant [q-bio]

Lorena Butinar, Martina Mohorčič, Valérie Deyris, Katia Duquesne, Gilles Iacazio, et al.. Prevalence and specificity of Baeyer–Villiger monooxygenases in fungi. Phytochemistry, 2015, 117, pp.144 - 153. ⟨10.1016/j.phytochem.2015.06.009⟩. ⟨hal-01500961⟩