Lipids and Their Trafficking: An Integral Part of Cellular Organization.

Catherine L Jackson (1, 2) , Laurence Walch (1, 2) , Jean-Marc Verbavatz (1, 2)

1 IJM (UMR_7592) - Institut Jacques Monod
2 USPC - Université Sorbonne Paris Cité

An evolutionarily conserved feature of cellular organelles is the distinct phospholipid composition of their bounding membranes, which is essential to their identity and function. Within eukaryotic cells, two major lipid territories can be discerned, one centered on the endoplasmic reticulum and characterized by membranes with lipid packing defects, the other comprising plasma-membrane-derived organelles and characterized by membrane charge. We discuss how this cellular lipid organization is maintained, how lipid flux is regulated, and how perturbations in cellular lipid homeostasis can lead to disease.

Mots clés: Golgi; VAP (VAMP-associated protein); amphipathic helix; cellular organization; endoplasmic recticulum; lipid transfer protein (LTP); lipid transport; membrane contact site; membrane packing defect; plasma membrane

Domaines: Biologie cellulaire; Biologie du développement

Catherine L Jackson, Laurence Walch, Jean-Marc Verbavatz. Lipids and Their Trafficking: An Integral Part of Cellular Organization.. Developmental Cell, 2016, 39 (2), pp.139-153. ⟨10.1016/j.devcel.2016.09.030⟩. ⟨hal-01494056⟩