MODELLING THE INTERSTRAND CROSS-LINKS IMPACT ON DNA STRUCTURE

Emmanuelle Bignon (1, 2) , Tomáš Dršata (3) , Elise Dumont (2) , Christophe Morell (1) , Filip Lankaš (3)

1 ISA - Institut des Sciences Analytiques
2 LC - Laboratoire de Chimie - UMR5182
3 IOCB / CAS - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Interstrand cross-links are highly cytotoxic oxidatively-generated DNA lesions. They result from abasic sites (Ap) reaction with an opposite purine. The aldehyde group of the abasic site condenses with the exocyclic amino group of the purine, leading to a covalent adduct, bonding the two strands. We plan to extend the modelling to other lesions for which structure can hardly be obtained by experimental means.

Domaines: Chimie; Modélisation et simulation

Emmanuelle Bignon, Tomáš Dršata, Elise Dumont, Christophe Morell, Filip Lankaš. MODELLING THE INTERSTRAND CROSS-LINKS IMPACT ON DNA STRUCTURE. 14th International Workshop on Radiation Damage to DNA, Mar 2016, Melbourne, Australia. ⟨hal-01490046⟩