. Côte-d-'azur, JB and PJ are Ph.D. students granted by Direction Générale de l'Armement (DGA)

R. Brackman, G. , C. , and T. , Quorum Sensing Inhibitors as Anti-Biofilm Agents, Current Pharmaceutical Design, vol.21, issue.1, pp.5-11, 2015.
DOI : 10.2174/1381612820666140905114627

J. Bzdrenga, D. Daudé, B. Rémy, P. Jacquet, L. Plener et al., Biotechnological applications of quorum quenching enzymes, Chemico-Biological Interactions, vol.267, p.28, 2016.
DOI : 10.1016/j.cbi.2016.05.028
URL : https://hal.archives-ouvertes.fr/hal-01521246

Y. Carmeli, N. Troillet, A. W. Karchmer, and M. H. Samore, Health and Economic Outcomes of Antibiotic Resistance in Pseudomonas aeruginosa, Archives of Internal Medicine, vol.159, issue.10, pp.1127-1132, 1999.
DOI : 10.1001/archinte.159.10.1127

J. Chessa, I. Petrescu, M. Bentahir, J. Van-beeumen, and C. Gerday, Purification, physico-chemical characterization and sequence of a heat labile alkaline metalloprotease isolated from a psychrophilic Pseudomonas species, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1479, issue.1-2, pp.265-274, 2000.
DOI : 10.1016/S0167-4838(00)00018-2

O. Ciofu, L. F. Mandsberg, T. Bjarnsholt, T. Wassermann, and N. Hoiby, Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants, Microbiology, vol.52, issue.10, pp.1108-1119, 2010.
DOI : 10.1128/AAC.00233-08

R. Daniels, J. Vanderleyden, and J. Michiels, Quorum sensing and swarming migration in bacteria, FEMS Microbiology Reviews, vol.28, issue.3, pp.261-289, 2004.
DOI : 10.1099/00221287-147-12-3249

S. P. Diggle, S. Matthijs, V. J. Wright, M. P. Fletcher, S. R. Chhabra et al., The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment, Chemistry & Biology, vol.14, issue.1, pp.87-96, 2007.
DOI : 10.1016/j.chembiol.2006.11.014

S. P. Diggle, K. Winzer, S. R. Chhabra, K. E. Worrall, M. Cámara et al., The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR, Molecular Microbiology, vol.70, issue.1, pp.29-43, 2003.
DOI : 10.1128/IAI.70.10.5635-5646.2002

Y. Dong, L. Wang, and L. Zhang, Quorum-quenching microbial infections: mechanisms and implications, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.96, issue.9, pp.1201-1211, 2007.
DOI : 10.1073/pnas.96.9.4832
URL : http://rstb.royalsocietypublishing.org/content/royptb/362/1483/1201.full.pdf

J. A. Driscoll, S. L. Brody, and D. M. Kollef, The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections, Drugs, vol.111, issue.3, pp.351-368, 2012.
DOI : 10.1136/bmj.316.7147.1771

S. Fetzner, Quorum quenching enzymes, Journal of Biotechnology, vol.201, 2015.
DOI : 10.1016/j.jbiotec.2014.09.001

M. J. Gambello and B. H. Iglewski, Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression., Journal of Bacteriology, vol.173, issue.9, pp.3000-3009, 1991.
DOI : 10.1128/jb.173.9.3000-3009.1991

R. García-contreras, Is quorum sensing interference a viable alternative to treat Pseudomonas aeruginosa infections? Front, 2016.

R. García-contreras, M. Martínez-vázquez, N. V. Guadarrama, A. G. Pañeda, T. Hashimoto et al., clinical isolates, Pathogens and Disease, vol.53, issue.Suppl A, pp.8-11, 2013.
DOI : 10.1093/jac/dkh223

R. García-contreras, B. Peréz-eretza, R. Jasso-chávez, E. Lira-silva, J. A. Roldán-sánchez et al., High variability in quorum quenching and growth inhibition by furanone C-30 in Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients, 2015.

M. Grosso-becerra, C. Santos-medellín, A. González-valdez, J. Méndez, G. Delgado et al., Pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity, BMC Genomics, vol.15, issue.1, pp.318-328, 2014.
DOI : 10.1093/bioinformatics/btq003

N. Grover, J. G. Plaks, S. R. Summers, G. R. Chado, M. J. Schurr et al., Acylase-containing polyurethane coatings with anti-biofilm activity, Biotechnology and Bioengineering, vol.101, issue.120, pp.2535-2543, 2016.
DOI : 10.1016/S0168-1656(02)00305-X

R. E. Hancock and D. P. Speert, Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment, Drug Resistance Updates, vol.3, issue.4, pp.247-255, 2000.
DOI : 10.1054/drup.2000.0152

M. Hentzer, Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors, The EMBO Journal, vol.22, issue.15, pp.3803-3815, 2003.
DOI : 10.1093/emboj/cdg366

J. Hiblot, G. Gotthard, E. Chabriere, E. , and M. , Characterisation of the organophosphate hydrolase catalytic activity of SsoPox, Scientific Reports, vol.66, issue.1, 2012.
DOI : 10.1107/S0907444909042073
URL : https://hal.archives-ouvertes.fr/hal-01772542

J. Hiblot, G. Gotthard, M. Elias, C. , and E. , Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox, PLoS ONE, vol.18, issue.9, 2013.
DOI : 10.1371/journal.pone.0075272.s010

S. Hraiech, J. Hiblot, J. Lafleur, H. Lepidi, L. Papazian et al., Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia, PLoS ONE, vol.38, issue.10, 2014.
DOI : 10.1371/journal.pone.0107125.s003
URL : https://hal.archives-ouvertes.fr/hal-01243714

K. Ivanova, M. M. Fernandes, A. Francesko, E. Mendoza, J. Guezguez et al., Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary Catheters, ACS Applied Materials & Interfaces, vol.7, issue.49, pp.27066-27077, 2013.
DOI : 10.1021/acsami.5b09489

L. Lauretti, M. L. Riccio, A. Mazzariol, G. Cornaglia, G. Amicosante et al., Cloning and characterization of bla VIM, a new integronborne metallo-?-lactamase gene from a Pseudomonas aeruginosa clinical isolate, Antimicrob. Agents Chemother, vol.43, pp.1584-1590, 1128.

L. A. Lavery, D. G. Armstrong, R. P. Wunderlich, M. J. Mohler, C. S. Wendel et al., Risk Factors for Foot Infections in Individuals With Diabetes, Diabetes Care, vol.29, issue.6, pp.1288-1293, 2006.
DOI : 10.2337/dc05-2425

J. Lee and L. Zhang, The hierarchy quorum sensing network in Pseudomonas aeruginosa, Protein & Cell, vol.362, issue.4, pp.26-41, 2014.
DOI : 10.1038/362446a0

T. Maeda, R. García-contreras, M. Pu, L. Sheng, L. R. Garcia et al., Quorum quenching quandary: resistance to antivirulence compounds, The ISME Journal, vol.181, issue.3, 2012.
DOI : 10.1073/pnas.0813199106
URL : http://www.nature.com/ismej/journal/v6/n3/pdf/ismej2011122a.pdf

J. P. Pearson, K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard et al., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes., Proceedings of the National Academy of Sciences, vol.91, issue.1, pp.197-201, 1994.
DOI : 10.1073/pnas.91.1.197

K. Poole, K. Krebes, C. Mcnally, and S. Neshat, Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon., Journal of Bacteriology, vol.175, issue.22, pp.7363-7372, 1993.
DOI : 10.1128/jb.175.22.7363-7372.1993

A. Price-whelan, L. E. Dietrich, and D. K. Newman, Pyocyanin Alters Redox Homeostasis and Carbon Flux through Central Metabolic Pathways in Pseudomonas aeruginosa PA14, Journal of Bacteriology, vol.189, issue.17, pp.6372-6381, 2007.
DOI : 10.1128/JB.00505-07

A. Rastogi, S. Sukumar, A. Hajela, S. Mukherjee, P. Dutta et al., The microbiology of diabetic foot infections in patients recently treated with antibiotic therapy: A prospective study from India, Journal of Diabetes and its Complications, vol.31, issue.2, 2016.
DOI : 10.1016/j.jdiacomp.2016.11.001

B. Rémy, L. Plener, M. Elias, D. Daudé, C. et al., Des enzymes pour bloquer la communication bact??rienne, une alternative aux antibiotiques???, Annales Pharmaceutiques Fran??aises, vol.74, issue.6, pp.413-420, 2016.
DOI : 10.1016/j.pharma.2016.06.005

B. Rémy, L. Plener, L. Poirier, M. Elias, D. Daudé et al., Harnessing hyperthermostable lactonase from Sulfolobus solfataricus for biotechnological applications, Scientific Reports, vol.5, issue.1, 2016.
DOI : 10.1021/bi00866a011

D. Ren, J. J. Sims, and T. K. Wood, Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone, Environmental Microbiology, vol.27, issue.11, pp.731-736, 2001.
DOI : 10.1073/pnas.96.4.1639

J. Richard, A. Sotto, and J. Lavigne, New insights in diabetic foot infection, World Journal of Diabetes, vol.2, issue.2, 2011.
DOI : 10.4239/wjd.v2.i2.24

P. Seng, M. Drancourt, F. Gouriet, L. Scola, B. Fournier et al., Ongoing Revolution in Bacteriology: Routine Identification of Bacteria by Matrix???Assisted Laser Desorption Ionization Time???of???Flight Mass Spectrometry, Clinical Infectious Diseases, vol.49, issue.4, pp.543-551, 1086.
DOI : 10.1086/600885

S. Sethupathy, K. G. Prasath, S. Ananthi, S. Mahalingam, S. Y. Balan et al., Proteomic analysis reveals modulation of iron homeostasis and oxidative stress response in Pseudomonas aeruginosa PAO1 by curcumin inhibiting quorum sensing regulated virulence factors and biofilm production, Journal of Proteomics, vol.145, pp.112-126, 2016.
DOI : 10.1016/j.jprot.2016.04.019

D. M. Sievert, P. Ricks, J. R. Edwards, A. Schneider, J. Patel et al., Antimicrobial-resistant pathogens associated with healthcareassociated infections summary of data reported to the national healthcare safety network at, Infect. Control Hosp. Epidemiol, vol.34, pp.2009-2010, 2013.

C. K. Stover, X. Q. Pham, A. L. Erwin, S. D. Mizoguchi, P. Warrener et al., Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen, Nature, vol.25, issue.6799, pp.959-964, 1038.
DOI : 10.1093/nar/25.17.3389

A. V. Sunder, P. D. Utari, S. Ramasamy, R. Van-merkerk, W. Quax et al., Penicillin V acylases from gram-negative bacteria degrade N-acylhomoserine lactones and attenuate virulence in Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, vol.101, issue.6, pp.253-269, 2016.
DOI : 10.1016/S0168-1656(02)00305-X

K. Tang and X. Zhang, Quorum Quenching Agents: Resources for Antivirulence Therapy, Marine Drugs, vol.110, issue.6, pp.3245-3282, 2014.
DOI : 10.1016/j.reactfunctpolym.2010.10.002

A. Ueda, C. Attila, M. Whiteley, and T. K. Wood, and fluorouracil is an antagonist, Microbial Biotechnology, vol.189, issue.1, pp.62-74, 2009.
DOI : 10.1099/00221287-148-1-87

M. A. Welsh and H. E. Blackwell, Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa, Cell Chemical Biology, vol.23, issue.3, pp.361-369, 2016.
DOI : 10.1016/j.chembiol.2016.01.006

M. Whiteley, M. G. Bangera, R. E. Bumgarner, M. R. Parsek, G. M. Teitzel et al., Gene expression in Pseudomonas aeruginosa biofilms, Nature, vol.97, issue.6858, pp.860-864, 1038.
DOI : 10.1073/pnas.160140297