Ferrocenyl derivatives of bisacodyl: synthesis and antimicrobial activity

Maité Sylla-Iyarreta Veitía (1, 2) , Meral Görmen (1, 2) , Fatma Trigui (3) , Clotilde Ferroud (3) , Mehdi El Arbi (3)

1 CMGPCE - Laboratoire de Chimie moléculaire, génie des procédés chimiques et énergétiques
2 CNAM - Conservatoire National des Arts et Métiers [CNAM]
3 LBMIE - Laboratoire de Biotechnologie Microbienne et d’Ingénierie des Enzymes (LBMIE), Centre of Biotechnology of Sfax

The antibacterial activity of bisacodyl, a drug used in therapeutic as laxative is described herein for the first time. Ten original ferrocenyl analogues have been synthesized via an efficient synthetic procedure using the McMurry coupling reaction. The antibacterial activity was investigated against Gram-positive and Gram-negative foodborne pathogens including Listeria monocytogenes, Escherichia coli, Enterococcus faecalis, Salmonella enterica, Micrococcus luteus and Staphylococcus aureus. The results showed that most of these compounds exhibit an excellent antimicrobial activity, and the bisacodyl analogues seemed to be more bactericides than bacteriostatic.

Mots clés: Bisacodyl; Ferrocene; Antibacterial

Domaines: Chimie organique; Chimie thérapeutique

Maité Sylla-Iyarreta Veitía, Meral Görmen, Fatma Trigui, Clotilde Ferroud, Mehdi El Arbi. Ferrocenyl derivatives of bisacodyl: synthesis and antimicrobial activity. Journal of Organometallic Chemistry, 2015, 794, pp.274-281. ⟨10.1016/j.jorganchem.2015.07.016⟩. ⟨hal-01487393⟩