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Article Dans Une Revue Journal of Biosciences Année : 2017

What history tells us XLII. A “new” view of proteins

Résumé

Circa 2000, it was usual among biologists to discuss about the new views on proteins : on protein folding, on the mechanisms of catalysis, on allostery. There was something common between these new views : to consider proteins (and macromolecules) as an ensemble of different conformations in dynamic equilibrium. There was however a debate to know whether this populational view was really new. In this articke I argue that there was something more in common between these new views : the conviction that the characteristics of proteins cannot be understood independently from the evolutionary history that generated them. I illustrate this with examples borrowed from four different areas of research on proteins. The case of proteins is emblematic of the impossibility to explain biological characteristics without putting them under the light of evolution.
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hal-01483777 , version 1 (06-03-2017)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Michel Morange. What history tells us XLII. A “new” view of proteins. Journal of Biosciences, 2017, ⟨10.1007/s12038-017-9673-x⟩. ⟨hal-01483777⟩
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