MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

Kévin Baranger (1) , Michel Khrestchatisky (1) , Santiago Rivera (1)

1 NICN - Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN

We have recently identified in a transgenic mouse model of Alzheimer's ă disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in ă Alzheimer's pathogenesis, which displays pro-amyloidogenic features and ă proteolytic processing of amyloid precursor protein (APP). Another group ă has reported that MT5-MMP processing of APP may release a novel ă neurotoxic APP fragment. Although MT5-MMP-mediated APP processing ă appears to be a key pathogenic step, we hypothesize that MT5-MMP may ă also contribute to AD pathogenesis through complementary mechanisms that ă involve the activation of pro-inflammatory pathways and/or APP ă trafficking.

Mots clés: Matrix metalloproteinases; Neurodegenerative disease; Trafficking; Neuroinflammation; IL-1β; Amyloidogenesis; Amyloid precursor protein

Domaines: Neurosciences [q-bio.NC]; Immunologie

Kévin Baranger, Michel Khrestchatisky, Santiago Rivera. MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?. Journal of Neuroinflammation, 2016, 13, ⟨10.1186/s12974-016-0633-4⟩. ⟨hal-01477833⟩