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Determinants of On-road Driving in Multiple Sclerosis

Résumé : Objective: To investigate the cognitive, visual, and motor deficits underlying poor performance on different dimensions of on-road driving in individuals with multiple sclerosis (MS). Design: Prospective cross-sectional study. Setting: MS clinic and driving simulator lab. Participants: Active drivers (N=102) with various types of MS. Interventions: Not applicable. Main Outcome Measures: Off-road cognitive, visual, and motor functions, as well as 13 specific driving skills. These skills were categorized into hierarchic clusters of operational, tactical, visuo-integrative, and mixed driving. Stepwise regression analysis was used to determine the off-road functions influencing performance on the on-road test and each cluster. Results: Visuospatial function (P=.002), inhibition (P=.008), binocular acuity (P=.04), vertical visual field (P=.02), and stereopsis (P=.03) best determined variance in total on-road score (unadjusted R2=.37). Attentional shift (P=.0004), stereopsis (P=.007), glare recovery (P=.047), and use of assistive devices (P=.03) best predicted the operational cluster (unadjusted R2=.28). Visuospatial function (P=.002), inhibition (P=.002), reasoning (P=.003), binocular acuity (P=.04), and stereopsis (P=.005) best determined the tactical cluster (unadjusted R2=.41). The visuo-integrative model (unadjusted R2=.12) comprised binocular acuity (P=.007) and stereopsis (P=.045). Inhibition (P=.0001) and binocular acuity (P=.001) provided the best model of the mixed cluster (unadjusted R2=.25). Conclusions: Our results provide more insights into the specific impairments that influence different dimensions of on-road driving and may be used as a framework for targeted driving intervention programs in MS.
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Submitted on : Wednesday, June 21, 2017 - 4:57:04 PM
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Hannes Devos, Maud Ranchet, Deborah Backus, Matt Abisamra, John Anschutz, et al.. Determinants of On-road Driving in Multiple Sclerosis. Archives of Physical Medicine and Rehabilitation, WB Saunders, 2017, 98 (7), pp.1332-1338.e2. ⟨10.1016/j.apmr.2016.10.008⟩. ⟨hal-01475850v3⟩



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