Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Sylvain Goutelle (1, 2) , Sandrine Roux (3) , Marie-Claude Gagnieu (4) , Florent Valour (3) , Sebastien Lustig (5) , Florence Ader (6, 7) , Frédéric Laurent (8) , Christian Chidiac (3, 8) , Tristan Ferry (8)

1 Service Pharmaceutique
2 Evaluation et modélisation des effets thérapeutiques
3 Department of Infectious Diseases
4 UF de Pharmacologie Spécialisée
5 LBMC UMR T9406 - Laboratoire de Biomécanique et Mécanique des Chocs
6 LegioPath - Pathogenèse des légionelles- Legionella pathogenesis
7 CIRI - Centre International de Recherche en Infectiologie
8 StaPath - Pathogénie des Staphylocoques – Staphylococcal Pathogenesis

The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.

Mots clés: OS; ARTICULATION HUMAINE

Domaines: Biomécanique [physics.med-ph]

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, et al.. Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections. Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp. 3148-3151. ⟨10.1128/AAC.02597-15⟩. ⟨hal-01464943⟩