Skip to Main content Skip to Navigation
Journal articles

Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Résumé : The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.
Mots-clés : ARTICULATION HUMAINE OS
Document type :
Journal articles
Complete list of metadata

Cited literature [13 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01464943
Contributor : Ifsttar Cadic <>
Submitted on : Wednesday, February 22, 2017 - 11:21:52 AM
Last modification on : Tuesday, July 20, 2021 - 5:20:07 PM
Long-term archiving on: : Tuesday, May 23, 2017 - 1:23:36 PM

File

ris00000075.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, et al.. Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, 60 (5), pp. 3148-3151. ⟨10.1128/AAC.02597-15⟩. ⟨hal-01464943⟩

Share

Metrics

Record views

408

Files downloads

499