Skip to Main content Skip to Navigation
Journal articles

The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite

Abstract : The involvement of collagen in bone biomineralization is commonly admitted, yet its role remains unclear. Here we show that type I collagen in vitro can initiate and orientate the growth of carbonated apatite mineral in the absence of any other vertebrate extracellular matrix molecules of calcifying tissues. We also show that the collagen matrix influences the structural characteristics on the atomic scale, and controls the size and the three-dimensional distribution of apatite at larger length scales. These results call into question recent consensus in the literature on the need for Ca-rich non-collagenous proteins for collagen mineralization to occur in vivo. Our model is based on a collagen/apatite self-assembly process that combines the ability to mimic the in vivo extracellular fluid with three major features inherent to living bone tissue, that is, high fibrillar density, monodispersed fibrils and long-range hierarchical organization.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-01461430
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Wednesday, February 8, 2017 - 10:45:53 AM
Last modification on : Tuesday, September 22, 2020 - 3:40:23 AM

Identifiers

Citation

Yan Wang, Thierry Azaïs, Marc Robin, Anne Vallee, Chelsea Catania, et al.. The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite. Nature Materials, Nature Publishing Group, 2012, 11 (8), pp.724-733. ⟨10.1038/NMAT3362⟩. ⟨hal-01461430⟩

Share

Metrics

Record views

235