Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2014

Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines

Résumé

Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.
Fichier principal
Vignette du fichier
Molecules Montana et al 2014.pdf (810.07 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01460539 , version 1 (20-04-2018)

Licence

Paternité

Identifiants

Citer

Marc Montana, Florian Correard, Omar Khoumeri, Marie-Anne Esteve, Thierry Terme, et al.. Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines. Molecules, 2014, 19 (9), pp.14987-14998. ⟨10.3390/molecules190914987⟩. ⟨hal-01460539⟩
175 Consultations
76 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More