TDAE-assisted synthesis of new imidazo[2,1-b]thiazole derivatives as anti-infectious agents - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2010

TDAE-assisted synthesis of new imidazo[2,1-b]thiazole derivatives as anti-infectious agents

Résumé

A series of new imidazo[2,1-b]thiazoles was prepared in moderate to good yields in a four step synthesis using the TDAE methodology from 6-chloromethyl-5-nitroimidazo[2,1-b]thiazole and keto esters, ketomalonates and ketolactams. All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two Gram positive and two Gram negative ones) and four yeasts. Among these synthesized 5-nitroimidazo[2,1-b]thiazoles, the compounds I and 6 showed potent antimicrobial activities against all candida. strains and compound 3e showed an interesting antifungal potential against Candida tropicalis. (C) 2009 Elsevier Masson SAS. All rights reserved.

Domaines

Chimie

Dates et versions

hal-01460233 , version 1 (07-02-2017)

Identifiants

Citer

Thierry Juspin, Michèle Laget, Thierry Terme, Nadine D Azas, Patrice Vanelle. TDAE-assisted synthesis of new imidazo[2,1-b]thiazole derivatives as anti-infectious agents. European Journal of Medicinal Chemistry, 2010, 45 (2), pp.840--845. ⟨10.1016/j.ejmech.2009.10.048⟩. ⟨hal-01460233⟩
65 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More