Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014

Agathe Boussaroque , Bécaye Fall (1) , Marylin Madamet (2) , Cheikhou Camara (3) , Nicolas Benoit (4, 2, 5) , Mansour Fall (6) , Aminata Nakoulima (7) , Pierre Dionne (8) , Kadidiatou Ba Fall , Bakary Diatta (6) , Yaya Diemé (1) , Boubacar Wade (9) , Bruno Pradines (2, 10)

1 Laboratoire d'étude de la chimiosensibilité du paludisme
2 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
3 Service des Urgences
4 IP-TPT - Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques
5 Centre National de Référence du Paludisme
6 Service de Réanimation Médicale
7 Service de pédiatrie
8 Maternité Hôpital Principal de Dakar
9 Chefferie
10 Centre National de Référence du Paludisme

The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected in 2012 and 2013 from patients residing in Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13: 472, 2014, http://dx.doi.org/10.1186/1475-2875-13-472). However, the N554H, Q613H, and V637I mutations were identified in the propeller region of K13 in 92 (5.5%) isolates in 2013 and 2014. There were five polymorphisms identified in the Plasmodium/Apicomplexa-specific domain (K123R, N137S, N142NN/NNN, T149S, and K189T/N).

Domaines: Maladies infectieuses

Agathe Boussaroque, Bécaye Fall, Marylin Madamet, Cheikhou Camara, Nicolas Benoit, et al.. Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014. Antimicrobial Agents and Chemotherapy, 2016, 60 (1), pp.624-627. ⟨10.1128/AAC.01346-15⟩. ⟨hal-01459954⟩