Antibacterial activities of fluorescent nano assembled triphenylamine phosphonium ionic liquids

Frédéric Brunel (1) , Christelle Lautard , Frédéric Garzino (2) , Suzanne Giorgio (2) , Jean M. Raimundo (2) , Jean M. Bolla , Michel Camplo (2)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille

Staphylococcus aureus, a Gram positive coccal bacterium is a major cause of nosocomial infection. We report the synthesis of new triphenylamine phosphonium ionic liquids which are able to self-assemble into multiwall nanoassemblies and to reveal a strong bactericidal activity (MIC = 0.5 mg/L) for Gram positive bacteria (including resistant strains) comparable to that of standard antibiotics. Time kill, metabolism and fluorescence confocal microscopy studies show a quasi-instantaneously penetration of the nanoassemblies inside the bacteria resulting of a rapid blocking (30 min) of their proliferation. As confirmed by rezasurin reduction monitoring, these compounds strongly affect the bacterial metabolism and a Gram positive versus Gram negative selectivity is clearly observed. These fluorescent phosphonium ionic liquid might constitute a useful tool for both translocation studies and to tackle infectious diseases related to the field of implantology. (C) 2016 Elsevier Ltd. All rights reserved.

Domaines: Chimie

Frédéric Brunel, Christelle Lautard, Frédéric Garzino, Suzanne Giorgio, Jean M. Raimundo, et al.. Antibacterial activities of fluorescent nano assembled triphenylamine phosphonium ionic liquids. Bioorganic and Medicinal Chemistry Letters, 2016, 26 (15), pp.3770-3773. ⟨10.1016/j.bmcl.2016.05.055⟩. ⟨hal-01459077⟩