The target cell genus does not matter.

Sophie Bleves (1) , Thibault G Sana , Romé Voulhoux (1)

1 LISM - Laboratoire d'ingénierie des systèmes macromoléculaires

Two type VI secreted phospholipases D of Pseudomonas aeruginosa were identified as trans-kingdom virulence effectors, targeting both prokaryotic and eukaryotic host cells. Each of them triggers killing bacterial competitors and internalization into non-phagocytic cells. These type VI lipolytic enzymes are widely distributed among pathogens and may constitute a conserved strategy.

Domaines: Biochimie, Biologie Moléculaire

Sophie Bleves, Thibault G Sana, Romé Voulhoux. The target cell genus does not matter.. Trends Microbiol., 2014, 22 (6), pp.304--6. ⟨10.1016/j.tim.2014.04.011⟩. ⟨hal-01458219⟩