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Article Dans Une Revue Chemistry - A European Journal Année : 2000

Membrane Properties of Archæal Macrocyclic Diether Phospholipids

O. Dannenmuller
  • Fonction : Auteur
K. Arakawa
  • Fonction : Auteur
T. Eguchi
  • Fonction : Auteur
K. Kakinuma
  • Fonction : Auteur
A.-M. Albrecht
  • Fonction : Auteur
M. Schmutz
Y. Nakatani
  • Fonction : Auteur

Résumé

Several biophysical properties of four synthetic archæal phospholipids [one polyprenyl macrocyclic lipid A and three polyprenyl double-chain lipids (B, C, D) bearing zero, one or four double bonds in each chain] were studied using differential scanning calorimetry, electron and optical microscopies, stopped-flow/light scattering and solid-state 2H-NMR techniques. These phospholipids gave a variety of self-organized structures in water, in particular vesicles and tubules. These assemblies change in response to simple thermal convection. Some specific membrane properties of these archæal phospholipids were observed: They are in a liquid-crystalline state over a wide temperature range ; the dynamics of their polyprenyl chains is higher than that of n-acyl chains; the water permeability of the membranes is lower than that of n-acyl phospholipid membranes. It was also found that macrocyclization remarkably improves the barrier properties to water and the membrane stability. This may be related to the adaptation of Methanococcus jannaschii to the extreme conditions of the deep-sea hydrothermal vents.

Domaines

Chimie

Dates et versions

hal-01458137 , version 1 (06-02-2017)

Identifiants

Citer

O. Dannenmuller, K. Arakawa, T. Eguchi, K. Kakinuma, Sylvie Blanc, et al.. Membrane Properties of Archæal Macrocyclic Diether Phospholipids. Chemistry - A European Journal, 2000, 6 (4), pp.645-654. ⟨10.1002/(SICI)1521-3765(20000218)6:4<645::AID-CHEM645>3.0.CO;2-A⟩. ⟨hal-01458137⟩
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