New backing layer for transdermal drug delivery systems: coatings based on fatty acid and beeswax on chitosan films

Bénédicte Rullier-Birat (1) , Sophie Cazalbou (1) , Maria Alejandra Nassar (1) , Sandrine Cavalie (1) , Audrey Tourrette (1)

1 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux

Fatty acids and beeswax are known to improve barrier properties of biodegradable materials. Thanks to their hydrophobic character, they can act as a barrier against water giving to the material more occlusive properties. This work was aimed at preparing fatty acid and beeswax coatings for a transdermal drug delivery system. In order to study occlusive properties of these coatings, water vapor permeability and contact angle measurements were carried out. The most homogeneous coatings were obtained from the beeswax mixture. Coatings made from emulsified beeswax exhibit high hydrophobic properties and relatively good mechanical properties compared to chitosan film without coatings.

Mots clés: Water vapor permeability; Transdermal drug delivery system; Fatty acid and beeswax coatings; Chitosan film

Domaines: Pharmacie galénique; Matériaux

Bénédicte Rullier-Birat, Sophie Cazalbou, Maria Alejandra Nassar, Sandrine Cavalie, Audrey Tourrette. New backing layer for transdermal drug delivery systems: coatings based on fatty acid and beeswax on chitosan films. Journal of Adhesion Science and Technology, 2015, 29 (4), pp.245-255. ⟨10.1080/01694243.2014.981982⟩. ⟨hal-01451889⟩