Aerobic metabolism and cardiac activity in the descendants of zebrafish exposed to pyrolytic polycyclic aromatic hydrocarbons

Abstract : The increase of anthropogenic activities on coastal areas induces discharges of Polycyclic Aromatic 16 Hydrocarbons (PAHs) in aquatic ecosystem. PAHs effects depend on their concentration and the way of 17 contamination, but also on the different developmental stages of the organism. Zebrafish were exposed to 18 relevant concentration of pyrolytic PAHs from the first meal (i.e. 5 day post fertilization, dpf) to mature adults. 19 Parental effect of this type of exposure was evaluated through the assessment of aerobic metabolic scope, cardiac 20 frequency and cardiac mRNA expression on larval and/or embryo progeny of contaminated fish. Our results 21 suggest that cardiac frequency increased in larval descendants of fish exposed to the environmental 22 concentration of pyrolytic PAHs (i.e. 5ng.g-1 of food), while a lack of effect on aerobic metabolism in 5 dpf 23 larvae was highlighted. A surexpression of mRNA related to the cardiac calcium transporting ATPase atp2a2a, a 24 protein essential for contraction, is in accordance with this increasing cardiac frequency. Even if cardiac 25 development genes cmlc1 and tnnt2a were not affected at early lifestages tested, complementary work on cardiac 26 structure could be interesting to better understand PAHs action. 27 28
Document type :
Journal articles
Complete list of metadatas

Cited literature [44 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01451554
Contributor : Christel Lefrancois <>
Submitted on : Wednesday, February 1, 2017 - 11:28:24 AM
Last modification on : Thursday, February 20, 2020 - 7:23:06 PM

Files

Lucas et al. 2014.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Julie Lucas, Prescilla Perrichon, Marine Nouhaud, Alexandre Audras, Isabelle Leguen, et al.. Aerobic metabolism and cardiac activity in the descendants of zebrafish exposed to pyrolytic polycyclic aromatic hydrocarbons. Environmental Science and Pollution Research, Springer Verlag, 2014, 21, pp.13888 - 13897. ⟨10.1007/s11356-014-3116-0⟩. ⟨hal-01451554⟩

Share

Metrics

Record views

237

Files downloads

1439