Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

Tarek Baati (1) , Bochra Bejaoui Kefi (2, 1) , Aïcha Aouane (3) , Leila Njim (4) , Florence Chaspoul (5) , Vasile Heresanu (6) , Abdelhamid Kerkeni (7) , Fadoua Neffati (4) , Mohamed Hammami (1)

1 INRAP - Institut National de Recherche et d'Analyse Physico-Chimique
2 Faculté des Sciences de Bizerte [Université de Carthage]
3 IBDML - Institut de Biologie du Développement de Marseille-Luminy
4 HFB - CHU Fattouma Bourguiba [Monastir]
5 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
6 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
7 Laboratoire de Biophysique [Monastir]

Titanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape. Ti-Nts were assessed for their safety, their kinetics of cellular uptake on U87-MG cell line and for genistein loading efficiency. No cytotoxic effect was observed under higher empty Ti-Nts concentrations up to 100 mu g mL(-1). The multiwalled tubular morphology was found to be an important parameter promoting high drug loading. The Ti-Nts could achieve higher genistein drug-loading content (25.2%) and entrapment efficiency (51.2%) leading to a controlled drug release as well as a higher cellular uptake of genistein-loaded- Ti-Nts which induces higher cytotoxicity and significant anti-migratory effect on U87-MG human glioblastoma astrocytoma, promising efficient antitumor activity.

Domaines: Biodiversité et Ecologie

Tarek Baati, Bochra Bejaoui Kefi, Aïcha Aouane, Leila Njim, Florence Chaspoul, et al.. Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines. RSC Advances, 2016, 6 (103), pp.101688--101696. ⟨10.1039/c6ra24569b⟩. ⟨hal-01444657⟩