Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Abstract : The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.
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Submitted on : Monday, January 23, 2017 - 11:22:26 AM
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Alexandra Testard, Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, et al.. Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩. ⟨hal-01443570⟩

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