Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Abstract : The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.
Type de document :
Article dans une revue
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01443570
Contributeur : Laurence Murillo <>
Soumis le : lundi 23 janvier 2017 - 11:22:26
Dernière modification le : mercredi 20 février 2019 - 10:10:22

Identifiants

  • HAL Id : hal-01443570, version 1
  • PUBMED : 16408791

Citation

Alexandra Testard, Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, et al.. Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.557-568. 〈hal-01443570〉

Partager

Métriques

Consultations de la notice

143