Patient-specific simulation of tidal breathing

Abstract : Patient-specific simulation of air flows in lungs is now straightforward using segmented airways trees from CT scans as the basis for Computational Fluid Dynamics (CFD) simulations. These models generally use static geometries, which do not account for the motion of the lungs and its influence on important clinical indicators, such as airway resistance. This paper is concerned with the simulation of tidal breathing, including the dynamic motion of the lungs, and the required analysis workflow. Geometries are based on CT scans obtained at the extremes of the breathing cycle, Total Lung Capacity (TLC) and Functional Residual Capacity (FRC). It describes how topologically consistent geometries are obtained at TLC and FRC, using a ‘skeleton’ of the network of airway branches. From this a 3D computational mesh which morphs between TLC and FRC is generated. CFD results for a number of patient-specific cases, healthy and asthmatic, are presented. Finally their potential use in evaluation of the progress of the disease is discussed, focusing on an important clinical indicator, the airway resistance.
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Communication dans un congrès
SPIE Medical Imaging, Feb 2016, Orlando, United States. 9788, pp.978818 2016, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. <10.1117/12.2216807>
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https://hal.archives-ouvertes.fr/hal-01443113
Contributeur : Catalin Fetita <>
Soumis le : dimanche 22 janvier 2017 - 14:50:05
Dernière modification le : samedi 18 février 2017 - 01:10:30

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Martin Walters, A.K. Wells, Ian P. Jones, Ian S. Hamill, Bart Veeckmans, et al.. Patient-specific simulation of tidal breathing. SPIE Medical Imaging, Feb 2016, Orlando, United States. 9788, pp.978818 2016, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. <10.1117/12.2216807>. <hal-01443113>

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