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Age-related differences in corticospinal excitability during a Go/NoGo task

Abstract : Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RT task in younger and older adults. Single-and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMG onset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.
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Contributor : Jean-Baptiste Melmi Connect in order to contact the contributor
Submitted on : Thursday, January 19, 2017 - 11:58:42 AM
Last modification on : Tuesday, October 19, 2021 - 10:58:52 PM

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Hakuei Fujiyama, Christophe Tandonnet, Jeffery J. Summers. Age-related differences in corticospinal excitability during a Go/NoGo task. Psychophysiology, Wiley, 2011, 48 (10), pp.1448-1455. ⟨10.1111/j.1469-8986.2011.01201.x⟩. ⟨hal-01440405⟩



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