J. A. Dudakov, A. M. Hanash, and M. R. Van-den-brink, Interleukin-22: Immunobiology and Pathology, Annu Rev Immunol, vol.33, pp.747-85, 2015.

H. Spits, D. Artis, M. Colonna, A. Diefenbach, D. Santo et al., Innate lymphoid cells-a proposal for uniform nomenclature, Nat Rev Immunol, vol.13, pp.145-149, 2013.

A. N. Mckenzie, H. Spits, and G. Eberl, Innate lymphoid cells in inflammation and immunity, Immunity, vol.41, pp.366-374, 2014.
URL : https://hal.archives-ouvertes.fr/pasteur-01402714

A. Diefenbach, M. Colonna, and S. Koyasu, Development, differentiation, and diversity of innate lymphoid cells, Immunity, vol.41, pp.354-365, 2014.

E. Montaldo, K. Juelke, and C. Romagnani, Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice, Eur J Immunol, vol.45, pp.2171-2182, 2015.

G. Eberl, D. Santo, J. P. Vivier, and E. , The brave new world of innate lymphoid cells, Nat Immunol, vol.16, pp.1-5, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01402712

G. Eberl, M. Colonna, D. Santo, J. P. Mckenzie, and A. N. , Innate lymphoid cells: a new paradigm in immunology, Science, vol.348, p.6566, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01402704

R. E. Mebius, P. Rennert, and I. L. Weissman, Developing lymph nodes collect CD4 + CD3 ? LTbeta + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells, Immunity, vol.7, pp.493-504, 1997.

M. G. Constantinides, H. Gudjonson, B. D. Mcdonald, I. E. Ishizuka, P. A. Verhoef et al., PLZF expression maps the early stages of ILC1 lineage development, Proc Natl Acad Sci USA, vol.112, pp.5123-5128, 2015.

C. S. Klose, E. A. Kiss, V. Schwierzeck, K. Ebert, T. Hoyler et al., A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells, Nature, vol.494, pp.261-265, 2013.

L. C. Rankin, J. R. Groom, M. Chopin, M. J. Herold, J. A. Walker et al., The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway, Nat Immunol, vol.14, pp.389-395, 2013.

S. Kirchberger, D. J. Royston, O. Boulard, E. Thornton, F. Franchini et al., Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model, J Exp Med, vol.210, pp.917-931, 2013.

N. Satoh-takayama, C. A. Vosshenrich, S. Lesjean-pottier, S. Sawa, M. Lochner et al., Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense, Immunity, vol.29, pp.958-970, 2008.
URL : https://hal.archives-ouvertes.fr/pasteur-01402754

M. Cella, A. Fuchs, W. Vermi, F. Facchetti, K. Otero et al., A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity, Nature, vol.457, pp.722-725, 2009.

G. F. Sonnenberg, L. A. Fouser, and D. Artis, Functional Biology of the IL-22-IL-22R Pathway in Regulating Immunity and Inflammation at Barrier Surfaces, Adv Immunol, vol.107, pp.1-29, 2010.

Y. Zheng, P. A. Valdez, D. M. Danilenko, Y. Hu, S. M. Sa et al., Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, Nat Med, vol.14, pp.282-289, 2008.
DOI : 10.1038/nm1720

N. Satoh-takayama, N. Serafini, T. Verrier, A. Rekiki, J. C. Renauld et al., The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells, Immunity, vol.41, pp.776-788, 2014.
URL : https://hal.archives-ouvertes.fr/pasteur-01090414

D. Artis and H. Spits, The biology of innate lymphoid cells, Nature, vol.517, pp.293-301, 2015.

S. A. Van-de-pavert and E. Vivier, Differentiation and function of group 3 innate lymphoid cells, from embryo to adult, pii: dxv052, 2015.

M. L. Robinette, A. Fuchs, V. S. Cortez, J. S. Lee, Y. Wang et al., Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets, Nat Immunol, vol.16, pp.306-317, 2015.

G. Sciume, K. Hirahara, H. Takahashi, A. Laurence, A. V. Villarino et al., Distinct requirements for T-bet in gut innate lymphoid cells, J Exp Med, vol.209, pp.2331-2338, 2012.

X. Guo, J. Qiu, T. Tu, X. Yang, L. Deng et al., Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection, Immunity, vol.40, pp.25-39, 2014.

P. Sathe, R. B. Delconte, F. Souza-fonseca-guimaraes, C. Seillet, M. Chopin et al., Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells, Nature communications, vol.5, p.4539, 2014.

J. Qiu, X. Guo, Z. M. Chen, L. He, G. F. Sonnenberg et al., Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora, Immunity, vol.39, pp.386-399, 2013.
DOI : 10.1016/j.immuni.2013.08.002
URL : https://doi.org/10.1016/j.immuni.2013.08.002

X. Guo, Y. Liang, Y. Zhang, A. Lasorella, B. L. Kee et al., Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota, Immunity, vol.42, pp.731-743, 2015.
DOI : 10.1016/j.immuni.2015.03.012
URL : http://europepmc.org/articles/pmc4725053?pdf=render

R. Basu, D. B. O'quinn, D. J. Silberger, T. R. Schoeb, L. Fouser et al., Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria, Immunity, vol.37, pp.1061-1075, 2012.
DOI : 10.1016/j.immuni.2012.08.024
URL : https://doi.org/10.1016/j.immuni.2012.08.024

H. Ahlfors, P. J. Morrison, J. H. Duarte, Y. Li, J. Biro et al., IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection, J Immunol, vol.193, pp.4602-4613, 2014.

C. Vonarbourg, A. Mortha, V. L. Bui, P. P. Hernandez, E. A. Kiss et al., Regulated Expression of Nuclear Receptor RORgammat Confers Distinct Functional Fates to NK Cell ReceptorExpressing RORgammat(+) Innate Lymphocytes, Immunity, vol.33, pp.736-751, 2010.
DOI : 10.1016/j.immuni.2010.10.017
URL : https://doi.org/10.1016/j.immuni.2010.10.017

R. Dhiman, M. Indramohan, P. F. Barnes, R. C. Nayak, P. Paidipally et al., IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion, J Immunol, vol.183, pp.6639-6645, 2009.
DOI : 10.4049/jimmunol.0902587
URL : http://www.jimmunol.org/content/jimmunol/183/10/6639.full.pdf

H. Guo and D. J. Topham, Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection, J Virol, vol.84, pp.7750-7759, 2010.

V. Male, T. Hughes, S. Mcclory, F. Colucci, M. A. Caligiuri et al., Immature NK cells, capable of producing IL-22, are present in human uterine mucosa, J Immunol, vol.185, pp.3913-3918, 2010.

Q. Tang, Y. O. Ahn, P. Southern, B. R. Blazar, J. S. Miller et al., Development of IL-22producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue, Blood, vol.117, pp.4052-4055, 2011.

X. Xu, I. D. Weiss, H. H. Zhang, S. P. Singh, T. A. Wynn et al., Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia, J Immunol, vol.192, pp.1778-1786, 2014.
DOI : 10.4049/jimmunol.1300039
URL : http://www.jimmunol.org/content/192/4/1778.full.pdf

E. Macho-fernandez, E. P. Koroleva, C. M. Spencer, M. Tighe, E. Torrado et al., Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells, Mucosal Immunol, vol.8, pp.403-413, 2015.
DOI : 10.1038/mi.2014.78
URL : https://www.nature.com/articles/mi201478.pdf

G. F. Sonnenberg, L. A. Monticelli, T. Alenghat, T. C. Fung, N. A. Hutnick et al., Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria, Science, vol.336, pp.1321-1325, 2012.
DOI : 10.1126/science.1222551
URL : http://europepmc.org/articles/pmc3659421?pdf=render

G. F. Sonnenberg, L. A. Monticelli, M. M. Elloso, L. A. Fouser, and D. Artis, CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut, Immunity, vol.34, pp.122-134, 2011.
DOI : 10.1016/j.immuni.2010.12.009
URL : https://doi.org/10.1016/j.immuni.2010.12.009

M. R. Hepworth, L. A. Monticelli, T. C. Fung, C. G. Ziegler, S. Grunberg et al., Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria, Nature, vol.498, pp.113-117, 2013.
DOI : 10.1038/nature12240
URL : http://europepmc.org/articles/pmc3699860?pdf=render

G. Gasteiger and A. Y. Rudensky, Interactions between innate and adaptive lymphocytes, Nat Rev Immunol, vol.14, pp.631-639, 2014.
DOI : 10.1038/nri3726
URL : http://europepmc.org/articles/pmc4504695?pdf=render

S. Wiles, C. S. Harker, J. Huett, A. Young, D. Dougan et al., Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium, Cell Microbiol, vol.6, pp.963-972, 2004.
DOI : 10.1111/j.1462-5822.2004.00479.x

H. F. Smith, R. E. Fisher, M. L. Everett, A. D. Thomas, R. R. Bollinger et al., Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix, J. Evol. Biol, vol.22, pp.1984-1999, 2009.

M. Frisch, B. V. Pedersen, and R. E. Andersson, Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark, Bmj, vol.338, p.716, 2009.
DOI : 10.1136/bmj.b716
URL : http://www.bmj.com/content/bmj/338/bmj.b716.full.pdf

T. Alonzi, D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert et al., Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver, Mol Cell Biol, vol.21, pp.1621-1632, 2001.

M. Eberl, H. Jomaa, and A. C. Hayday, Integrated immune responses to infection-cross-talk between human gammadelta T cells and dendritic cells, Immunology, vol.112, pp.364-368, 2004.

E. E. Nieuwenhuis, M. F. Neurath, N. Corazza, H. Iijima, J. Trgovcich et al., Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice, Proc Natl Acad Sci USA, vol.99, pp.16951-16956, 2002.

E. Narni-mancinelli, J. Chaix, A. Fenis, Y. M. Kerdiles, N. Yessaad et al., Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor, Proc Natl Acad Sci USA, vol.108, pp.18324-18329, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00672199

C. Thakur, Y. Lu, J. Sun, M. Yu, B. Chen et al., Increased expression of mdig predicts poorer survival of the breast cancer patients, Gene, vol.535, pp.218-224, 2014.

Y. Liao, G. K. Smyth, and W. Shi, featureCounts: an efficient general purpose program for assigning sequence reads to genomic features, Bioinformatics, vol.30, pp.923-930, 2014.

M. E. Ritchie, B. Phipson, D. Wu, Y. Hu, C. W. Law et al., limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic acids research, vol.43, p.47, 2015.

G. K. Smyth, Linear models and empirical bayes methods for assessing differential expression in microarray experiments, Stat Appl Genet Mol Biol, vol.3, p.3, 2004.

D. J. Mccarthy and G. K. Smyth, Testing significance relative to a fold-change threshold is a TREAT, Bioinformatics, vol.25, pp.765-771, 2009.